Evaluation of the Efficacy and Safety of Intranasally Administered Ketamine and Midazolam for Paediatric Pre Medication
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2018, Vol 17, Issue 4
Abstract
Objective: An evaluation of the efficacy and safety of intra nasally administered Ketamine and Midazolam for paediatric premedication. Materials and methods: The study was a prospective randomized double blind study involving 90 ASA grade I and II paediatric patients scheduled for elective surgical procedures of less than 2 hours duration; all these patients received the drug by nasal route in a double blind manner (20 minutes prior to induction) and were divided into three groups. Group M received intranasal midazolam 0.2mg/kg; Group MK1 received intranasal midazolam 0.2mg/kg and ketamine 2mg/kg; Group Mk2 received intranasal midazolam 0.2mg/kg and ketamine 4mg/kg. Results: The number of patients with an acceptable local effects score(3,4), sedation score(3,4) and anxiety level score(3,4) was significantly higher in Group Mk1 and Group Mk2 than in group M(p<0.05) .The percentage of patients with an acceptable cooperation level score (3,4) was more in Group MK2 at 15 and 20 minutes as compared to Group M(p<0.05)where as in group MK1, it was significantly better than in Group M only at 20 minutes(p<0.05). Conclusion: Intranasal Ketamine (esp. in higher dosage of 4mg/kg) and midazolam when given in combination to preschool children as a premedicant achieves better sedation, anxiolysis and cooperation without increased incidence of adverse effects as compared to midazolam alone without an increased incidence of side effects.
Authors and Affiliations
Dr. Sumeet Chugh, Dr. Neetu Chaudhary
Keywords
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- EP ID EP373691
- DOI 10.9790/0853-1704174851.
- Views 59
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