Evaluation of the Genotoxic and Antigenotoxic Potential of Plantago major Methanolic Extract
Journal Title: International Journal of Pharmaceutical and Medicinal Reserach - Year 2016, Vol 4, Issue 5
Abstract
Plantago major L. (Plantaginaceae) is a perennial herb with rosette of leaves found throughout India and widely utilized traditional medicine of Indian-Ayurvedic and Chinese-medicine system. The present study was conducted to evaluate the in vivo genotoxic and/or antigenotoxic potential of P. major methanolic extract (PmME) using Organization for Economic Co-operation and Development (OECD) guidelines. The genotoxic and antigenotoxic potential of PmME was assayed using the comet assay on lymphocyte, the micronucleus (MN) and chromosomal aberration (CA) tests in bone marrow cells of albino mice. The results exhibited that none of the tested doses of PmME demonstrated genotoxic effects by the comet test, or clastogenic effects of the MN test. On the other hand, for all cells evaluated, the three tested doses of the PmME promoted inhibition of DNA damage induced by cyclophosphamide. Based on these results, it was concluded that PmME contains no genotoxic or clastogenic effects in our experimental conditions. However, it showed a significant decrease in DNA damage induced by cyclophosphamide. These findings therefore suggest that the antigenotoxic properties of PmME may be of great pharmacological importance and safe to use as an immunomodulatory agent.
Authors and Affiliations
Sanjeev Karmakar, Danswrang Goyary, Aadesh Upadhyay, Dhruba Kumar Jha, Pronobesh Chattopadhyay
Keywords
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