Evaluation of the Haemostatic Activities of Sida corymbosa in Rats
Journal Title: Journal of Pharmaceutical Research International - Year 2015, Vol 5, Issue 6
Abstract
Aims: To evaluate the anti-haemorrhagic activity of the leaf extract of Sida corymbosa in Wistar albino rats, a plant used to arrest bleeding in ethnomedical practices. Methods: The acute toxicity test was carried out in rats. The haemostatic activities of the extract were investigated using the tail bleeding time and amount of bleeding in rats; effects on haematological parameters were also evaluated in Wistar rats. Preliminary phytochemical analysis was conducted to detect the phytoconstituents of the extract of Sida corymbosa. Results: In this study, the oral LD50 of the extract was found to be greater than 5 g/kg. Administration of the extract to rats for 14 days produced a dose-dependent and significant (Pā¤0.05) decrease in bleeding time and quantity of blood loss in pre-treated rats. On oral administration of the extract, the effects of the treatment on haematological parameters ā White blood cells, Red blood cell, haemoglobin concentration were not significantly different from control. Conclusion: This study has shown that Sida corymbosa has constituents with anti-haemorrhagic properties in rats thereby providing scientific validation for the ethnomedical use of the plant in bleeding control.
Authors and Affiliations
Lucy B. John-Africa, Mercy Aboh
Keywords
Related Articles
- EP ID EP344464
- DOI 10.9734/BJPR/2015/15676
- Views 103
- Downloads 0
Anti-proliferative Effect of Isoflavones Isolated from Soybean and Soymilk Powder on Lymphoma (DG 75) and Leukemia (CEM) Cell Lines
Aim: Isoflavones in soybean have been linked to reduced risk of some cardiovascular diseases as well as some type of cancers. Extensive epidemiological, in-vitro and animal data suggests lower incidence of cardiovascular...
Development and Validation of Method for Determination of Clobetasol Propionate and Salicylic Acid from Pharmaceutical Dosage Form by HPLC
Aim: A new reverse phase high performance liquid chromatography (RP-HPLC) method for the quantitative determination of Clobetasol Propionate and Salicylic Acid in ointment was developed and validated as per ICH (Internat...
Study on the Chemical Constituents and Anti-inflammatory Activity of Essential Oil of Petiveria alliacea L.
Aims: To study and report the chemical constituents and anti-inflammatory activity of essential oil of Petiveria alliacea L (Phytolaccaceae) from Nigeria. Study Design: The study involves the distillation of essential oi...
Healthcare Costs of Pediatric Acne in the Medicaid Population: A Retrospective Analysis
Despite the substantial economic burden of acne, little is known about healthcare costs in Medicaid-enrolled pediatric patients with acne. The objective of this study is to examine factors associated with healthcare cost...
Effect of Ethanolic Leaf Extract of Psidium guajava Linn. (Guava) in Alloxan-Induced Diabetic Rats
Effect of water ā soluble components of ethanolic leaf extract of Psidium guajava Linn. on blood glucose and cholesterol levels in alloxan-induced diabetic male albino wistar rats was evaluated. A total of 30 male albino...