Evaluation of tissue 5´-Nucleotidase as tumor marker in breast and brain tumors using receiver operating characteristic curve
Journal Title: Journal of Cancer Research & Therapy - Year 2013, Vol 1, Issue 10
Abstract
The pursuit of the ideal tumor marker has generated many testes for using in the diagnosis and management of cancer. Several of which are now widely available. The objective of the current study was to evaluate 5´-NT activity as a tumor marker for breast & brain cancer. Receiver Operating Characteristic curve (ROC) & other statistical parameters were used to investigate this possibility. The results throughout this study supported the motion that 5´-NT specific activity can be considered as an acceptable marker for breast and brain cancer when the comparison was made with benign group. For the breast cancer, the true-positive rate (sensitivity) of tissue extract 5´-NT specific activity was 85.7% while the false-positive rate (1-specificety) was 11.11%, meanwhile both the predictive value of positive test (pv+) and the negative predictive value (pv-) was 88.9% for breast cancer women and benign group. The true positive rate (sensitivity) of tissue extract’s 5´-NT specific activity in the case of brain cancer was (80.4%) with a false-positive rate (1-specificity) equal to (13.6%). The predictive value of positive test (pv+) when compared malignant brain group with benign group was (88.09%), while the negative predictive values (pv-) was found to be (78.04%). The area under ROC curve for tissue extract 5´-NT specific activity were 0.955 (95% CI 0.907–1.0) and 0.922 (95% CI 0.867-0.978) for breast and brain tumor respectively.
Authors and Affiliations
Hasan HR, Mathkor TH, Aziz MA
Keywords
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- EP ID EP551825
- DOI 10.14312/2052-4994.2013-33
- Views 77
- Downloads 0
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