EVALUATION OF TRACK ETCH MEMBRANE AS A SURROGATE FOR EX-VIVO DRUG PERMEATION STUDIES
Journal Title: International Journal of Pharmaceutical Sciences and Drug Research - Year 2014, Vol 6, Issue 3
Abstract
The track etch membranes has attracted the attention of researchers, as a kind of novel material, for their various applications such as precise separation of biological cells, detection of biomolecules and controlled drug release, especially for pharmaceutical and biomedical applications. In the present study, the efficacy of track etch membrane over goat skin for the Ex-vivo permeation of silver sulfadiazine gel has been investigated with the objective to evaluate track etch membrane as a surrogate for biological membrane owing to ethical issues and scarce availability of biological skins. The percent cumulative drug release from silver sulfadiazine gel using track etch membrane and goat skin were obtained as 18.18 % and 20.99 % respectively. The results obtained from track etch membrane and goat skin was similar with only a slight difference in percent drug diffusion which might be because of the lipids present in animal skin. Track etch membrane has the potential to mimic the animal skin for such ex-vivo drug diffusion studies with certain additional advantages such as sufficient mechanical strength and ruggedness. It can be efficiently reused and also surpasses the ethical issues involved with the use of biological membrane.
Authors and Affiliations
Ravish Garg, Priti Girotra, Shailendra Kumar Singh, Dinesh Kumar, S. K. Chakarvarti
Keywords
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