EXCISION AND INCISION WOUND HEALING POTENTIAL OF SABA FLORIDA (Benth) LEAF EXTRACT IN RATTUS NOVERGICUS
Journal Title: International Journal of Pharmaceutical and Biological Research - Year 2010, Vol 1, Issue 4
Abstract
Saba florida (Benth) belongs to the family Apocynaceae. It is very abundant in undisturbed forest and coastal regions in Africa. It is a folkloric medicine for a variety of ailments including skin ulcer. However there are no scientific reports on wound healing activity of the plant Saba florida (Benth).This study was carried out to evaluate the wound healing potential of Saba florida leaf extract in Rattus novergicus as experimental animals. All experiments were conducted following standard procedures. The extract in the form of an ointment was used for evaluating the wound healing potential in excision wound model. In the incision wound model , the extract was administered orally in graded doses of 100, 200 and 400 mg/kg b.w. Saba florida leaf extract demonstrated higher percentage of wound contraction in the excision wound model compared to the standard (Povidone iodine ointment) and the control. In the incision wound model healing rate was dose dependent. In both excision and incision wound models, wound surface protein increased and wound surface microbial load decreased after days. The healing or wound contraction elicited by Saba florida leaf extract in this investigation following topical and oral administration strongly support the verbal claim of traditional doctors on the use of this plant.
Authors and Affiliations
OMALE JAMES , ISAAC AYIDE VICTORIA
Keywords
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