Exercise-induced time-dependent changes in plasma BDNF levels in people with schizophrenia
Journal Title: Journal of Novel Physiotherapy and Physical Rehabilitation - Year 2018, Vol 5, Issue 1
Abstract
Objective: To investigate the short and long-term outcomes of a concurrent exercise protocol (CEP) on plasma Brain-derived neurotrophic factor (BDNF) levels and the effect of this intervention in the self-esteem and mental health in people with schizophrenia (SZ). Methods: In this quasi-experimental study, 15 participants underwent a structured, supervised and group based CEP for 12 weeks (the sessions were performed 3 times a week for 60 minutes). In order to verify the short- and long-term effects of exercise on BDNF levels, blood samples of 15 ml were collected pre-intervention and on the 4th, 8th and 12th week(s) after intervention started. To evaluate self-esteem, the Rosemberg Self-esteem Scale was used, and the general mental health status was measured through the General Health Questionnaire-12 (GHQ-12). Both questionnaires were applied before and after intervention. Results: BDNF plasma levels increased significantly at the 12 th week(s) when compared to baseline and in 4 weeks periods. There were no observed changes on self-esteem neither a trend of improvement in the GHQ at the post-intervention phase when compared to the baseline. Finally, the CEP reduced significantly anthropometric variables. Conclusion: The CEP induced time-dependent modulation on BDNF levels in individuals with SZ, increasing its levels only in a long-term period.
Authors and Affiliations
Fuhr Laira, Lavratti Caroline, da Silva Ivy Reichert Vital, Reinaldo Gustavo Pereira, de Carvalho Nathan Ono, de Oliveira Jordana Lectzow, Wagner Luciane Carniel, Ribeiro Jerri, Elsner Viviane Rostirola
Keywords
Related Articles
- EP ID EP301035
- DOI 10.17352/2455-5487.000056
- Views 75
- Downloads 0
Facilitating Improvements in Interprofessional Pain Management
Pain is a global phenomenon in which it has been estimated that 20% of adults and 8% of children suffer from at any one time of whom 10% suffer chronic pain [1,2]. Pain is the leading reason for primary care consultation...
A Review of the Possible Effects of Physical Activity on Low-Back Pain
Objective: Low back pain (LBP) represents the most prevalent and costly repercussion from musculoskeletal injury in the work place. This review examines the earlier and current research reported on the significance of ph...
Right Ventricular Dysfunction is related with Poor Exercise Tolerance in Elderly Patients with Heart Failure with Preserved Ejection Fraction
Background: Exercise intolerance (EI) is a cardinal feature in subjects with heart failure with preserved ejection fraction (HFpEF). Factors related to EI in such patients are not completely understood. The association b...
Introducing Competency-Based Education Based on the Roles that Physiotherapists Fulfil
Introduction: Although there has been a shift towards competency-based medical education in the past decade, littleliterature is available about the specific use of competency-based education in physiotherapy education....
Exploring the Extent of Restoration of Voluntary Movements, Function, Quality of Life and Cost of Formal Care in Dense Strokes Treated by the Optokinetic Chart Stimulation Based OKCSIB Protocol: A Prospective Pilot Randomised Case Controlled Study
Background: Stroke remains one of the largest causes of impairment and disability globally. Stroke involves high costs to the health economy.