Exocyclic enaminones as building blocks for synthesis of bioactive polyheterocyclic compounds
Journal Title: JOURNAL OF ADVANCES IN CHEMISTRY - Year 2014, Vol 10, Issue 6
Abstract
The reaction of exocyclic enaminones namely, 2-(dimethylaminomethylene)-3,4-dihydro-2H-naphthalen-1-one, 3-(dimethylaminomethylene)-thiochroman-4-one and 2-(dimethyl-aminomethylene)-indane-1,3-dione, each with heterocyclic diazonium salts afforded the respective hydrazones which undergo either in situ dehydrative cyclization or cyclized by heating with acetic acid to give polycyclic compounds. The structure of all the newly synthesized products were confirmed by elemental and spectral (IR, IH NMR, Mass) data. Also, the biological activity of some of the prepared compounds was tested against some microorganisms and promising results were obtained.
Authors and Affiliations
Magda A. Abdallah, Thoraya A. Farghaly, Mohamed R. Abdel Aziza
Keywords
Related Articles
- EP ID EP652741
- DOI 10.24297/jac.v10i6.880
- Views 169
- Downloads 0
Decolorization and Biodegradation of basic violet dye by fungal- bacterial consortia
The present study was aimed to test the ability of Penicillium citrinum MTCC 8009, Aspergillusterreus MTCC 3006, Bacillus cohnii and their consortia to decolorize basic violet dye. Different parameters such as initial dy...
SYNTHESIS AND CHARACTERIZATION OF ALUMINIUM-BARIUM NITRATE MATRIX COMPOSITES
In this experimental study the Aluminum based Metal Matrix Composites were synthesized by means of melt stir casting set up in an economic manner without sacrificing the potential properties of constituent materials. The...
Synthesis and physico-chemical studies of a novel noncentrosymmetric heptacoordinated cadmium(II) compound containing a tripodal amine, CdCl2[N(C2H6N)3]2
A new noncentrosymmetric Cd(II) complex with thetripodal amine tris(2-aminoethyl)amine, CdCl2[N(C2H6N)3]2, has been prepared and characterized by single crystal X-ray diffraction, solid state NMR and IR spectroscopies. I...
Phosphorylation and Promising In-Vitro Antimicrobial Activity of Some New Organosulfur Compounds
During the past few decades, interest has been rapidly growing in gaining insight into the properties and transformations of thiosemicarbazide and their derivatives due to their appreciable pharmacological activities. Di...
AN EXPERIMENTAL STUDY ON THE PERFORMANCE OF VERTICAL BASIN SOLAR STILL
In the present study, a new experimental approach is proposed to enhance the performances of the conventional single slope solar still using vertical basin at inner wall surfaces. Main objectives of this study are, to in...