Experimental evaluation of effects of a pyrimidine derivative 4CPTP on cardiovascular system
Journal Title: International Journal of Biomedical and Advance Research - Year 2016, Vol 7, Issue 9
Abstract
Aim: To study the effects of pyrimidine derivative 4CPTP on cardiovascular system. Material and methods: Ionotropic and chronotropic effects of 4CPTP were studied using rabbit heart and frogs heart in situ preparation. Dogs blood pressure preparation was used to assess the effects of 4CPTP on blood pressure. Results: The test compound, like phenobarbitone produced dose dependent decrease in heart rate and amplitude of contractions of rabbit and frog heart and decrease in blood pressure in dogs. Conclusions: 4 CPTP possesses negative ionotropic and negative chronotropic action along with hypotensive action in animal models.
Authors and Affiliations
Prem Kumar Verma, Garima Bhutani, Rahul Saini, Seema Rani
Keywords
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- EP ID EP367031
- DOI 10.7439/ijbar.v7i9.3618
- Views 77
- Downloads 0
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