Experimental Study of the New Non-Opioid Analgesic Pyrodazol and Ketorolac in the Rats

Journal Title: Macedonian Journal of Medical Sciences (MJMS) - Year 2013, Vol 6, Issue 3

Abstract

Aim: To search the new analgesics we studied the antinociceptive activity of the new derivative 5Hpyrrolo [1,2-a]¬imidazole in comparison with this of the morphine and ketorolac. Material and Methods: The analgesia was evaluated on hot plate and tail-flick thermal nociceptive stimulation models by intragastric administration of ketorolac and by intramuscular injection of morphine. Results: On the hot plate model ED50 value was per body weight 0.34 (0.18 - 0.63) mg/kg of the pyrodazol /i.g, 1.00 (0.59 - 1.70) mg/kg/of the ketorolac/ i. g. in 90 minutes post administration. On the hot plate model in 0.3 - 1.3 mg/kg/doses i.m the pirodazol is similar to morphine hydrochloride in dose 2.5 mg/kg i.m. On the tail-flick model ED50 values of the pyrodazol and ketorolac are 1.9 (1.12 - 3.23) mg/kg /i.g and 3.0 (2.08 - 4.32) mg/kg/i. g, respectively. Conclusion: The obtained data may allow to suggest that on thermal nociceptive stimulation models the pyrodazol exceeds the ketorolac and on the hot plate models it is similar to the morphine hydrochloride.

Authors and Affiliations

Oleh Yadlovskiy| State Institution Institute of Pharmacology and Toxicology of National Academy of Medical Sciences of Ukraine, Eugene Potie str. 14, Kiev 03680, Ukraine, Tatiana Bukhtiarova| State Institution Institute of Pharmacology and Toxicology of National Academy of Medical Sciences of Ukraine, Eugene Potie str. 14, Kiev 03680, Ukraine, Anatoliy Demchenko| State Institution Institute of Pharmacology and Toxicology of National Academy of Medical Sciences of Ukraine, Eugene Potie str. 14, Kiev 03680, Ukraine

Keywords

Related Articles

Patelar Instability: Medial Patellofemoral Ligament Reefing Versus Medial Patellofemoral Ligament Reconstruction

Although more than 100 operative procedures have been described for the treatment of patellar instability, there is no single universally successful procedure. Careful physical and imaging examination should be perform...

Breast Cancer among Urban Nigerian Women: Appraising Presentation and the Quality of Care

Introduction: Late presentation is the hallmark of breast cancer among Nigerians. Awareness of the disease is low and care of this condition has not received adequate attention from Government. Health education to impr...

Ochratoxin A Toxic Effect on Rat Kidneys and the Potential Protective Effect of Ginseng: Histopathologic, Histochemical, and Image Analysis Morphometric Studies

Background: Ochratoxin A (OA), a secondary fungal metabolite, produced by Aspergillus and Penicillium strains and it is known to cause severe nephrotoxicity in animals and humans. Aim: The effects on the histology and...

In Vitro Characterization of Stem Cells from Human Exfoliated Deciduous Teeth (SHED)

Stem cells from human exfoliated deciduous teeth (SHED) provide a new attractive source for stem cells; in this study we further characterize SHED. SHED were isolated, differentiated using osteogenic/ odontogenic diffe...

Oral Health Status of Individuals with Cleft Lip, Cleft Palate or Both in a Nigerian Population

Background: Cleft lip and/ or palate (CL/P) deformities are congenital anomalies with fissures of either the lip, palate or both combined. The altered oral anatomy causes physiological changes and diminished self clean...

Download PDF file
  • EP ID EP8934
  • DOI 10.3889/MJMS.1857-5773.2013.0314
  • Views 340
  • Downloads 22

How To Cite

Oleh Yadlovskiy, Tatiana Bukhtiarova, Anatoliy Demchenko (2013). Experimental Study of the New Non-Opioid Analgesic Pyrodazol and Ketorolac in the Rats. Macedonian Journal of Medical Sciences (MJMS), 6(3), 227-231. https://europub.co.uk./articles/-A-8934