Exploring Novel Topological Descriptors: Geometric-Harmonic and Harmonic-Geometric Descriptors for HAC and HAP Conjugates

Journal Title: Acadlore Transactions on Applied Mathematics and Statistics - Year 2024, Vol 2, Issue 1

Abstract

In this investigation, the exact formulas for geometric-harmonic (GH), neighborhood geometric-harmonic (NGH), harmonic-geometric (HG), and neighborhood harmonic-geometric (NHG) indices were systematically evaluated for hyaluronic acid-curcumin (HAC) and hyaluronic acid-paclitaxel (HAP) conjugates. Through this evaluation, a comprehensive quantitative assessment was conducted to elucidate the structural characteristics of these conjugates, highlighting the intricate geometric and harmonic relationships present within their molecular graphs. The study leveraged these indices to illuminate the complex interplay between geometric and harmonic properties, providing a novel perspective on the molecular architecture of HAC and HAP conjugates. This analytical approach not only sheds light on the structural nuances of these compounds but also offers a unique lens through which their potential in drug delivery applications can be assessed. Graphical analyses of the results further enhance the understanding of these molecular properties, presenting a detailed visualization that complements the quantitative findings. The integration of these topological descriptors into the study of HAC and HAP conjugates represents a significant advance in the field of medicinal chemistry, offering valuable insights for researchers engaged in the development of innovative drug delivery systems. The findings underscore the utility of these descriptors in characterizing the molecular topology of complex conjugates, setting the stage for further exploration of their applications in therapeutic contexts.

Authors and Affiliations

Ali Raza, Fikadu Tesgera Tolasa

Keywords

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  • EP ID EP732912
  • DOI 10.56578/atams020103
  • Views 37
  • Downloads 0

How To Cite

Ali Raza, Fikadu Tesgera Tolasa (2024). Exploring Novel Topological Descriptors: Geometric-Harmonic and Harmonic-Geometric Descriptors for HAC and HAP Conjugates. Acadlore Transactions on Applied Mathematics and Statistics, 2(1), -. https://europub.co.uk./articles/-A-732912