Expression of NF-κB in oral squamous cell carcinoma and paracancerous tissues and its significance
Journal Title: 口腔疾病防治 - Year 2019, Vol 27, Issue 6
Abstract
Objective To investigate the expression and significance of NF-κB in oral squamous cell carcinoma and paracancerous tissues. Methods Cancerous and paracancerous tissues about 5 mm outside the tumor boundary were cut from 47 patients with OSCC. NF-κB expression in these tissues were detected by the immunohistochemical SP method and compared with that in 32 normal oral mucosa tissues. Results The average optical density (OD value) of immunohistochemical-positive cells in cancer tissues and paracancerous tissues was higher than that in normal tissues, and the difference was statistically significant (P < 0.001). There was no significant difference in the OD values between cancer tissues and paracancerous tissues (P=0.356). The rate of NF-κB positive expression in cancer tissue and paracancerous tissue was significantly higher than that in normal mucosa tissue, and the difference was statistically significant (P < 0.001). There was no significant difference in the rate of NF-κB positive expression between cancer tissues and paracancerous tissues (P=0.117), but the rate of moderate-to-strong positive expression in cancer tissues was significantly higher than that in paracancerous tissues (P < 0.001). Conclusion NF-κB may be involved in the development of OSCC.
Authors and Affiliations
GUI Xinwei, YAO Xiaowu, CHEN Shisheng, LU Zizheng, LIN Minxiao, PENG Yu
Keywords
Related Articles
- EP ID EP623703
- DOI 10.12016/j.issn.2096-1456.2019.06.004
- Views 184
- Downloads 0
Effect of three kinds of medium molecular weight proteins on the corrosion resistance of Ni-Ti and stainless steel arch wires
Objective To explore the influence and mechanism of different types of proteins on the corrosion resistance of alloy to provide a reference for the safe application and surface modification of nickel-titanium (Ni-Ti) and...
Effect of laser-etched pure titanium surface on early proliferation of MG63 cells
Objective To investigate the effect of a laser-etched pure titanium surface on proliferation of the human osteosarcoma cell line MG63 and to provide a basis for study of implant surface modification. Methods The pure tit...
Research progress on the factors influencing the biological characteristics of dental pulp stem cells
Dental pulp stem cells (DPSCs) are mesenchymal stem cells derived from dental pulp tissue with self-renewal, high proliferative capacity and multidirectional differentiation potential. Under appropriate induction conditi...
The relationship between maternal periodontal disease and preterm low birth weight
Preterm low birth weight newborns are prone to complications during growth and development, such as growth retardation and infectious diseases, and the mortality rate of high-risk infants is higher than that of healthy n...
Effect of endoplasmic reticulum stress on the osteogenic differentiation of periodontal ligament cells under continuous static pressure
Objective To study the effect of continuous static pressure on the endoplasmic reticulum of human periodontal ligament cells (hPDLCs) and the mechanism of osteogenic differentiation.Methods hPDLCs cultured in vitro were...