EXPRESSION OF NF-ΚBMRNA IN ASTHMA RATS LUNG BASED ON THE EFFECT OF DIFFERENT TCM TREATMENT
Journal Title: Asian Pacific Journal of Microbiology Research (APJMR) - Year 2017, Vol 1, Issue 1
Abstract
To detect expression of NF-κB gene in the asthmatic rats lung tissue to explore the effect of NF-κB in asthma rats airway remodeling based on Real-time quantitative PCR. Then to research the effect of different TCM interventions for its role. Asthma rat models were prepared by injecting ovalbumin (OVA) into the abdominal cavity and inhalation of aerosol, and intervented by the different TCM treatment methods，example for body resistance-strengthening, lung-diffusing, lung-diffusing and body resistance-strengening. Then detected expression of NF-κB gene in the asthmatic rats lung tissue based on Real-time quantitative PCR. And compared lung coefficient between the rats in each group. The results showed that the three prescriptions can all reduce the expression of NF-ΚB in the lung tissue, there is statistical significant difference between model group and lung-diffusing and lung-diffusting and body resistance-strengthening group. The three treatment methods can reduce the lung coefficient. NF-κBmRNA is Gene NF-κB in airway remodeling in asthmatic rats has important value and different TCM treatment is effect to it. This is consistent with TCM theory understanding to asthma. The pathogenesis of asthma is deficiency of healthy Qi and exuberance of evils, then the treatment principles should strengthen healthy Qi to remove toxic substance.
Authors and Affiliations
Li Xueliang, Xu Zhaoxia, Qian Peng, Cheng Lijun, Yan Haixia, Guo Rui, Wang Yiqin
Keywords
Related Articles
- EP ID EP403980
- DOI 10.26480/ajmr.01.2017.01.04
- Views 67
- Downloads 0
ANTIBACTERIAL EFFECT OF ETHANOL EXTRACT OF CAMELLIA SINENSIS L AGAINST ESCHERICHIA COLI
The aim studywas carried out to determine the potentialantibacterial effect of ethanol extract of Camellia sinensis L against E. coli. All 30 strains of E.coli isolated from urine culture of hospitalized patients Hospita...
N-METHYLENE PHOSPHONIC CHITOSAN: A NOVEL SELF- ASSEMBLED TEMPLATE FOR ENAMEL REMINERALIZATION
To evaluate the feasibility of phosphonic chitosan membrane in guiding enamel remineralization. We design a organic molecules model to induced the crystallization of hydroxyapatite with 3D-structure in a controllable way...
SIMULATION STUDY ON RELIEFING NEGATIVE INFLUENCE OF DAMAGE ROOTS IN COAL MINING SUBSIDENCE AREA
In the process of coal mining, surface subsidence leads to plant root injury. In this study, the mitigation effects of an arbuscular mycorrhizal fungus (AMF) inoculation on the growth of root injured alfalfa were investi...
AUTOMATED DEVICE FOR IN-SERVICE MONITORING OF OVERHEAD PIPES, BURNERS AND TURBINES IN PETROCHEMICAL PLANTS
In present scenario in service health monitoring of turbines, boilers and overhead pipes in petrochemical and gas industries are more concern for higher perspective of research because a single day shutdown of such type...
PREVALENCE AND IDENTIFICATION OF UROPATHOGENS IN EASTERN NEPAL AND UNDERSTANDING THEIR ANTIBIOGRAM DUE TO MULTIDRUG RESISTANCE AND ESBL
This study was basically aimed at identifying the diversity of uropathogens; their drug response like multi-drug resistance (MDR) or extended spectrum β-lactamase (ESBL); and the evaluation of empirical treatment. Betwee...