Extended spectrum beta-lactamase production and biofilm formation in Klebsiella pneumoniae isolates from urinary tract samples: A tertiary care hospital experiencev
Journal Title: Indian Journal of Pharmacy and Pharmacology - Year 2018, Vol 5, Issue 1
Abstract
Multidrug resistant Gram negative bacteria belonging to family Enterobacteriaceae are responsible for urinary tract infections UTIs that are difficult to treat Nosocomial and community acquired UTIs are known to be existing with resistance recently Higher drug resistance among these healthcare associated pathogenic bacteria increases the mortality morbidity rates and the medical costs UTIs caused by Klebsiella pneumoniae Kpneumoniae isolates are a major public health problem because of their multidrugresistance to third generation cephalosporins and for their ability to produce extended spectrum beta lactamases ESBLs To accesses the formation of biofilm formation and ESBL production especially in Kpneumoniae isolates from urine samples this study has been designed in a tertiary care medical college hospital in Mangalore Dakshina Kannada District Karnataka India According to established standard methods about 80 urine samples containing K pneumoniae isolates were characterized and subjected for screening to antibiotic susceptibility test using Kirby Bauer disc diffusion and and presumptive ESBL production by double disk synergy test DDST In this study we found that 55 6875 were found to be biofilm producers 19 2375 isolates were ESBL producers and all them produced biofilm K pneumoniae isolates producing ESBL had a significantly greater capacity to form strong biofilm 724 than non ESBL producing K pneumoniae isolates 2758Keywords Urinary tract infections Klebsiella pneumoniae Multidrug ESBL production Biofilmnbsp
Authors and Affiliations
Amar Sunil Lobo, MS Moosabba, Rouchelle Tellis, Ronald Roche
Keywords
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- EP ID EP478528
- DOI 10.18231/2393-9087.2018.0001
- Views 80
- Downloads 0
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