Fabrication and characterization of CurcuminNanoemulgel to Overcome the Challenges in Opthalmic Drug Delivery System
Journal Title: Saudi Journal of Medical and Pharmaceutical Sciences - Year 2018, Vol 4, Issue 1
Abstract
Abstract:Major challenge in ophthalmic drug delivery system is to locate the drug in precorneal site for some time as the applied dose has been washed out quickly in the lachrymal drainage. As well as it has been always a challenge in the drug delivery to formulate poorly soluble compound as conventional ophthalmic delivery like eye drops. Hence the purpose of the present study is to formulate ophthalmic in-situnanoemulgels which are generally liquids at room temperature but exhibit sol‐to‐gel phase transition on the ocular surface due to change in specific physicochemical parameter like ionic strength, pH or temperature. The formulation was so designed to prolong the precorneal resident time thereby getting sustained delivery of drug and to improve bioavailability of poorly soluble model drug of curcumin by distributing it in nano globules of dispersed system. Different parameters of fabricated nanoemulgel like gelling capacity, gelation temperature, droplet size analysis, stability study, and refractive index, viscosity, Scanning Electron Microscopy (SEM) and drug release profile are evaluated. The physico-chemical evaluation reveals good rheological properties with instantaneous gelling capacity. Fourier Transform Infrared analysis (FTIR) study showed absence of incompatibility between the drug and polymer. The globular size found in nanometer range (below 200nm) and uniformity in size distribution (ploydispersity index 0.215-0.53) is studied by Malvern Zetasizer. Accelerated stability analysis ascertained the stability of formulation after storing at 40°C ± 2°C/75% RH ± 5% RH for 3 months. The drug release study of the formulations revealed sustained release of drug for the study period of 5 hours ranging from 31.87±2.12 to 61.77%±1.27. The developed thermosensitivenanoemulgel formulation is an effective ophthalmic delivery for getting sustained action of poorly soluble compound like curcumin. Keywords:Nanoemulgel; Curcumin; In-situ gel; dispersed system.
Authors and Affiliations
Pintu Kumar De, Soumen Rakshit
Keywords
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