Fabrication of microspheres and characterization of antimicrobial and anti-inflammatory activity isolated fraction from total alcoholic extract of Cassia Fistula (Linn.) in carrageenan-Type-IV induced inflammatory rats
Journal Title: International Journal of Experimental Research and Review - Year 2023, Vol 32, Issue 3
Abstract
The Cassia fistula Linn is known as the golden shower tree. It’s also referred to as a "disease killer" in Ayurvedic medicine. The current study investigates the effect and estimate of antimicrobial and Anti-inflammatory activity guided fraction isolated from alcoholic extract of Cassia fistula (Linn.) root on carrageenan-Type IV induced Inflammatory rats for using Column fraction of alcoholic extract of root of Cassia fistula (Linn.) An in vivo carrageenan-induced paw edoema model was used to confirm further the anti-inflammatory effect of the fraction aloe-emodin and physcion-loaded microspheres. This study was designed first time for the isolation of alcoholic fraction of aloe emodin and Physcion by root extract and screening of pharmacological activities of Cassia fistula. Aloe-emodin and Physcion fraction demonstrated antibacterial and antifungal effectiveness against the studied pathogens in a dose-dependent manner, according to anti-microbial activity. 50 mg/ml concentration of Physcion-containing microspheres and aloe emodin's antibacterial efficacy against tested pathogens. The anti-inflammatory activity of Aloe emodin and Physcion was found in an equal manner. Both Microsphere samples were found capable of controlling the inflammation till 6 hours. According to the findings of this research, the chosen plant extracts have an immediate anti-inflammatory effect. There are three stages during which carrageenan-induced inflammation mediators are released.
Authors and Affiliations
Beldar Shamshad Bee, Rakesh Kumar Jat, Sufiyan Ahmad
Keywords
Related Articles
- EP ID EP720671
- DOI 10.52756/ijerr.2023.v32.021
- Views 52
- Downloads 0
Women Empowerment in India since 1947: A Critical Analysis
The issue of women's empowerment is not new, this is an early concept. To empower the nation, we should empower the women. Discrimination between men and women, domestic violence, lack of education, lack of awareness abo...
Reinfection of Chickenpox for the fourth time in an older adult
CPeople with chickenpox often gain lifelong immunity after one infection. In most cases, chickenpox's natural immunity provides significant protection against reinfection. However, patients with a second reinfection have...
First record of tail bifurcation in Tokey Gecko (Gekko gecko) from the Kaziranga, Assam, India : a field observation
The Tokay Gecko (Gekko gecko) is the second largest surviving Gecko species and are distributed across much of South-East Asia, Southern China and Northeastern India and Nepal. In Kaziranga landscape Tokay Gecko are fair...
Idol immersion in Ichhamati river and its impact on water quality parameters
A preliminary study was undertaken in Ichhamati river, Bongaon, N-24 Parganas, West Bengal to evaluate the impact of idol immersion after Durga puja on water quality parameters. Different important physico-chemical param...
Iodine mediated cascade oxidative functionalization, cyclisation and annulation reactions
Molecular iodine has a huge application in the field of electrophilic cyclisation reactions, oxidation, oxidative cyclisation, multi-component reactions, ring opening, cyclisation, rearrangement, oxidative cross coupling...