FABRICATION OF PULSATILE DELIVERY MULTIPARTICULATE SYSTEM OF POORLY WATER SOLUBLE CARVEDILOL PHOSPHATE
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2012, Vol 3, Issue 9
Abstract
Pulsatile drug delivery system is required to satisfy the needs of chronotherapy. Among solids, multiparticulates have its own advantages. Pulsatile drug delivery system provides better therapy with many of the actives. Rupturable pulsatile drug delivery system consists of a drug core; swelling layer of a super disintegrant; and an insoluble, water-permeable polymeric coating. Upon water ingress, the swellable layer expands, resulting in the rupturing of outer membrane followed by drug release. The active pharmaceutical ingredient selected was Carvedilol Phosphate, deposited on sugar pellets as first layer. The second layer composed of swelling excipient, had crospovidone, L–substituted hydroxy propyl cellulose and sodium starch glycolate. Third and the outer most layer was based on ethyl cellulose. The release after lag time was fast and complete, when crospovidone was used as a swelling agent. In contrast, a sustained release was achieved after the lag time, when L–substituted hydroxy propyl cellulose and sodium starch glycolate were used as swelling agents. Fast release would be preferable in the present case. Optimal level of crospovidone to achieve a fast and complete release of Carvedilol phosphate was 33%. Outer membrane, formed using aqueous dispersion of ethyl cellulose was suitable enough to rupture sufficiently ensuring fast drug release, compared to stronger ethyl cellulose membrane formed using organic solution. It was possible to design multiparticulates of carvedilol phosphate having a suitable release profile.
Authors and Affiliations
DK Singh , Sheela Yadav , SU Nigade , Sushilkumar Poddar
Keywords
Related Articles
- EP ID EP161275
- DOI -
- Views 100
- Downloads 0
EFFECT OF VITIS VINIFERA AGAINST TRITON X 100 INDUCED HYPERLIPIDAEMIA IN RATS
To evaluate the effect of Vitis vinfera fruit juice (VVFJ) against Triton X 100 induced hyperlipidaemia. Wister strain rats were treated with atorvastatin (ATOR-10mg/kg, p.o.), low and high dose of Vitis vinifera fruit j...
METHOD DEVELOPMENT AND VALIDATION FOR THE ESTIMATION OF FLUPIRTINE MALEATE IN BULK AND PHARMACEUTICAL DOSAGE FORMS USING UV-VIS SPECTROPHOTOMETRY
The present study describes a simple, accurate, precise and cost effective UV-VIS Spectrophotometric method for the estimation of Flupirtine an analgesic drug in bulk and pharmaceutical dosage form. The solvent used is m...
PRELIMINARY PHYTOCHEMICAL SCREENING AND HPLC ANALYSIS OF FLAVONOID FROM METHANOLIC EXTRACT OF LEAVES OF ANNONA SQUAMOSA
The present paper deals with the phytochemical screening of therapeutic importance from Annona squamosa leaves, an important medicinal plant. This study involves the preliminary screening, qualitative thin layer ch...
WOUND HEALING ACTIVITY OF ETHANOL EXTRACT OF PSEUDARTHRIA VISCIDA LINN
The wound healing activity of topically applied ethanol extract of Pseudarthria viscida was evaluated in wistar rat by excision wound model for a period of 12 days. The extract was prepared as ointment form (5 and 10% w/...
NANOPARTICLE: AN OVERVIEW OF PREPARATION, CHARACTERIZATION AND APPLICATION
In the last 30 years, particle size reduction technologies turned from an exploratory approach into a mature commercial drug delivery platform. Nanonization technologies have gained a special importance due to a steadily...