Factors Associated with Platelet Transfusions in Neonates Admitted in Intensive Care Unit in a Tertiary Care Centre
Journal Title: International Journal of Contemporary Medical Research - Year 2017, Vol 4, Issue 6
Abstract
Introduction: Neonatal thrombocytopenia (TP) is a commonly encountered problem in intensive care unit during hospital stay and platelet transfusion remains a mainstay of treatment. No study has clear data on the prevalence, causes of TP and effect of platelet transfusions in neonates. Present study was undertaken to investigate the cause for neonatal TP and transfusion practice in our institute. This would be helpful in improving guidelines and thereby reducing unnecessary transfusions and multiple donor exposures. Material and methods: 220 neonates who received platelet transfusions are analyzed prospectively during the study period of 24 months. Both neonatal and maternal factors which leads to neonatal TP was evaluated and indication for platelet transfusion was analyzed. Results: Low birth weight (74.5%), preterm babies (64.5%), pregnancy induced hypertension (PIH) (34.5%), maternal infections (28.2%) are major factors which contributed to the development of neonatal TP. 58.2% of neonates received single (128/220) and 41.8% received multiple platelet transfusions (92/220). Multiple platelet transfusions were more in necrotizing enterocolitis (NEC) (‘p’ value=0.010), intrauterine growth retardation (IUGR) (‘p’ value=0.026), hospital stay (‘p’ value=0.001), maternal infection (‘p’ value=0.003) and gestational diabetes mellitus (‘p’ value=0.002) and neonates belongs to severe and very severe (‘p’=0.001) TP categories. Conclusion: Single or multiple neonatal and maternal factors were involved in causing neonatal TP which in turn led to platelet transfusions. Most of the neonates in our study had bleeding manifestations and received platelet transfusions within 1 to 5 days of birth and mortality was higher with neonates who receives multiple transfusion.
Authors and Affiliations
Ramanathan T, Maya Devi S, K. C Usha
Keywords
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