Factors influencing healing of fungal keratitis under treatment: A clinical study
Journal Title: Indian Journal of Clinical and Experimental Ophthalmology - Year 2016, Vol 2, Issue 3
Abstract
Purpose: To study the local and general factors influencing healing of fungal keratitis. To evaluate the effects of various antimycotic treatment regimens of fungal keratitis. Method: The patients were taken up from those attending the out-patient department of ophthalmology of Nehru hospital attached to B.R.D Medical College Gorakhpur from June 2006 to October 2007. All cases of corneal ulcer with clinical features of fungal keratitis and cases of corneal ulcer with positive 10% potassium hydroxide mount1,2 were selected, detailed history taken and examination done under (a) general examination, (b) systemic examination and detailed ocular examination along with blood investigations and 10% potassium hydroxide mount1,2 preparation. Treatment evaluation and follow up was done regularly for the period of one month, progression and treatment response noted and parameters were recorded .the ulcer was taken: Healed: If the epithelial defect had healed with negative fluorescein staining and there was no progressive stromal infiltration. Delayed healing: If the size of ulcer decreased but not fully healed and still require further active treatment and Failed: If the size of ulcer remained same or increased or ulcer got perforated requiring active surgical intervention. Result: 47 pts were included in study, 5 patients did not turn up. 18 patients (42.86%) leave the study with successful healing of corneal ulcer, 9 patients (21.43%) required further treatment due to delayed healing response and treatment failure occurred in 15 patients(35.71%) requiring active surgical treatment in form of conjunctival hooding, Amniotic membrane graft, evisceration etc. Conclusion: From the observation of this study it can be concluded that fungal keratitis is a suppurative, ulcerative disease of cornea, with a poor visual outcome even with the best efforts due to inability of highly sensitive and specific tools. Disease is more common in patients with reduced immunity, trauma with vegetative matter, low socio-economic status and injudicious use of steroids. There is also big lack of specific and effective fungicidal drugs. All available anti-fungal drugs are very slow acting and prevent the growth of fungus only, without killing it. At present the most effective drug is topical 5% Natamycin, which is also fungi-static and slow acting.
Authors and Affiliations
Ramyash Singh Yadav, Brij Mohan Rao, Praveen Kumar, Akash Srivastva
Keywords
Related Articles
- EP ID EP241474
- DOI -
- Views 462
- Downloads 0
Clinical profile and visual outcome of patients presenting with penetrating ocular trauma to a tertiary care hospital
Introduction: To identify the cause of penetrating ocular trauma; demographic, clinical profile and visual outcome of the patients presenting with penetrating ocular trauma to a tertiary care hospital. Materials and Meth...
Phaco chop versus stop and chop nucleotomy techniques: A comparative evaluation
To perform a comparative evaluation of phaco chop versus stop and chop nucleotomy techniques in phacoemulsificationMaterials and Methods 60 patients with uncomplicated senile cataract were included in this study which we...
Study of impact of diabetes mellitus on corneal central thickness and endothelial parameters in Indian eyes
Aim The purpose of the study is to find the impact of diabetes mellitus on central thickness and endothelial parameters of cornea when compared with non diabetic patients and in relation to duration of disease and glycae...
Indian Journal of Clinical and Experimental Ophthalmology, July-September,2016;2(3): 195-200 195 Causes of pediatric cataract in rural population of North India
Abstract Aims: To identify the causes of childhood cataract in rural population of north India with special emphasis on potentially preventable causes. Study design: Cross-sectional, observation study. Place and Duration...
Refraction-seeking behaviour among young people presenting to a medical college hospital of Bihar
With an objective to enquire about availability of primary or secondary level facilities for refraction and explore reasons for approaching a tertiary OPD despite awareness of the same a prospective study was conducted o...