Family of nuclear peroxisome proliferator — activated receptors (PPARs): biological role in metabolic adaptation Part III. PPARg in energy homeostasis and formation of metabolic syndrome, hepatosteatosis, cardiovascular conditions and fibrosis (report 1)
Journal Title: Український журнал сучасних проблем токсикології - Year 2017, Vol 77, Issue 1
Abstract
Objective. Analysis and summary of the current concept of biological role of nuclear peroxisome proliferator-activated receptor gamma (PPARγ) in the body, that is a transcription factor, simulating the expression of target genes that regulate different chains of adipogenesis, thermogenesis, energy homeostasis, providing balance of glucose and sensitivity of cells to insulin, secretion of adipokines, anti-inflammatory, and anti-fibrotic effects. Materials and methods. Analytical review of scientific publications was performed using abstract databases of scientific libraries and text database of methodological and biological publications PubMed. Results. Biological and physiological role of PPARγ in the body has been established. Its important role in the maintenance of energy homeostasis, hormonal secretion of fatty tissue has been found, as well as anti-proliferative, antioxidative, and anti-fibrotic effects upon its activation have been noticed. It was noted that PPARγ polymorphism or its dysfunction under the exposure to pesticides and other xenobiotics contributes to the formation of metabolic syndrome, type 2 diabetes mellitus, hepatosteatosis, obesity, chronic inflammation, and fibrosis.
Authors and Affiliations
G. M. Balan, N. M. Bubalo, V. O. Bubalo, P. G. Zhminko, V. A. Babych
Keywords
Related Articles
- EP ID EP306061
- DOI -
- Views 156
- Downloads 0
Study of the effect of four generic lambda-cyhalothrin pesticides on the reproductive function of male wistar han rats
Introduction. Objective is to identify hazard and asses reproductive toxicity risk of four generic lambda-cyhalothrin pesticides of different purity on male Wistar Han rats. Methods. Lambda-cyhalothrin (LC1 — 97 %, LC2 —...
Regulation of diisodecyl phthalate plasticizer in the air of working zone
Objective. Based on the analysis and compilation of the literature data and own studies on toxicological characteristics of diisodecyl phthalate plasticizer, substantiation of its tentative safe exposure level in the air...
Hygienic assessment of toxicodynamics peculiarities and mechanism of action of oxyacetamide class herbicide (flufenacet) on homoiotherms and human body
Analysis of literature data regarding toxic properties of a new oxyacetamide class herbicide, flufenacet, in acute, subchronic, and chronic experiments among different species of animals was performed. It was established...
Studying the history of synthesis and chemical structure of pyrethrins and synthetic pyrethroids, and mutagenicity of pyrethroids in the in vivo test for micronucleus induction (literature review and data of own studies)
Introduction. Pyrethroids are analogues of natural pyrethrins, primarily isolated from plants of the genus Pymthrum, a family of Asteraceae known for their insecticidal properties. Objective. To study literature data on...
Justification of an alternative method for determination of toxicity of perfume and beauty products by in vitro method on a short-term suspension cell culture-cattle spermatozoa (literature review)
Introduction. Based on the literature data and directive documentation, the main reasons for the use of alternative methods for determining the toxic effects of perfume and beauty products are set out. Methods — alternat...