FAP INHIBITORS: IN DIABETIC NEPHROPATHY?
Journal Title: WORLD JOURNAL PHARMACY AND PHARMACEUTICAL SCIENCE - Year 2017, Vol 6, Issue 9
Abstract
FAP inhibitor increases the endogenous level of FGF-21which may help in various Metabolic disease, Diabetes and Diabetic complication. Animal model have shown FGF-21 has protected renal damage in Diabetic animal model. However inhibition by FAP inhibitor and raised level of endogenous FGF-21,such raised endogenous FGF-21 have nephroprotective effect have not yet evaluated but FGF-21 mimetic drugs are in trial for Diabetes and metabolic disorder even FGF-21 MIMETICS are not evaluated for Diabetic nephropathy. Probable benefits of FAP inhibitors are highlighted based on evidence and study report.
Authors and Affiliations
Dr. Navneet Omprakash Soni
Keywords
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