Features of Cellular and Humoral Immunity Functioning in Patients with Juvenile Rheumatoid Arthritis
Journal Title: Біль. Суглоби. Хребет - Year 2015, Vol 4, Issue 20
Abstract
The objective was to examine the state of cellular and humoral immunity in children with juvenile rheumatoid arthritis. The study involved 48 patients with juvenile rheumatoid arthritis, 24 patients with reactive arthritis and 22 apparently healthy children. It was found that juvenile rheumatoid arthritis is associated with a likely decrease of CD3+-, CD4+-, CD8+-, CD16+-lymphocytes levels in peripheral blood, high levels of IgA, IgE, TNF-α, IL-4, IL-8 and the unchanged parameters of IgM and IgG, which is associated with chronization of rheumatoid process. The need for close monitoring and long-term treatment of patients in remission causes CD8+-lymphocytes deficiency and high rates of CD4+/CD8+, CD3+/CD16+, IgЕ, IL-4. The course of reactive arthritis is accompanied by low content of CD3+-cells and unchanged immunoglobulin levels in peripheral blood.
Authors and Affiliations
H. A. Pavlyshyn, T. A. Kovalchuk, O. R. Boiarchuk, T. V. Hariian
Keywords
Related Articles
- EP ID EP215149
- DOI -
- Views 113
- Downloads 0
Clinical and Pathogenetic Significance of Osteoassociated Microelements in the Joint Diseases. Report II: Microelementosis in the Hair
The relevance. Microelementosis (imbalance of certain microelements in the body, ME) is considered as one of the most important clinical and pathogenetic components of degenerative and inflammatory joint diseases. ME can...
Anesthetic Mechanism of Myeloacupuncture in Joints аnd Spine Pathology
The article presents a literature review on the application of such method of reflexotherapy acupuncture as myeloacupuncture used in the pathology of the peripheral joints and spine. It is theoretically grounded and ass...
New recommendations for local therapy of knee osteoarthritis and study of ketoprofen efficiency: literature review and results of own researches
Background. The main complaint of osteoarthritis (OA) patients is a moderate or severe pain, and the drugs most frequently used to reduce it are the non-steroidal anti-inflammatory drugs. Objective: to examine the effici...
Early Rheumatoid Arthritis without Radiographic Erosions: MRI Diagnostic Capabilities
The results of clinical and radiological examination of 65 patients with early rheumatoid arthritis with joint syndrome duration up to 12 months were presented in the article. The incidence of radiographic erosions in co...
Angiopathy in ankylosing spondylitis
Background. Ankylosing spondylitis is a chronic progressive systemic autoimmune rheumatic disease of the spine, peripheral joints, sacroiliac joints, enthesis, ligamentous apparatus and internal organs, and related to r...