FEATURES OF CHANGES IN THE INDICATORS OF T-CELL IMMUNITY IN PATIENTS WITH DIFFERENT CONTROLLING OF BRONCHIAL ASTHMA AND THEIR PROGNOSTIC VALUE
Journal Title: Астма и Аллергия - Year 2019, Vol 1, Issue 3
Abstract
The aim: to determine the prognostic assessment of T-cell immunity changes which are based on the study of their features in bronchial asthma (BA) patients with its different controllability. Materials and methods. 133 BA patients were examined: 11 patients with controlled, 63 patients with partially controlled and 59 patients with uncontrolled BA. The control group consisted of 36 volunteers. The content of leukocytes, the relative and absolute quantity of lymphocytes, pan-T cells, T-helper cells, cytotoxic T-lymphocytes, immunoregulatory index (IRI), T-cell proliferative response to phytohemagglutinin (PHA) in lymphocyte blast transformation reaction (LBTR), as well as the character and frequency of these indicators changes were determined. Results . In controlled BA a decrease in the content of pan-T and T-helper cells, an increase in the quantity of cytotoxic T-lymphocytes were detected, which in 44.4 % of cases were resulted in a decrease of IRI. In the greater part of patients with partial BA control the reference and elevated T-helper content, a decrease in the quantity of cytotoxic T-cells and IRI were found, which are distinctive signs of the breakdown of adaptive immunological mechanisms. In patients with uncontrolled BA increased T-cell content, a decreased cytotoxic T-lymphocytes quantity and increased IRI were found, which indicated immunological disadaptation. The suppression of LBTR to PHA was recorded in only 24.6 % of these patients, which may be an indirect sign of steroid resistance. Conclusions . Individual changes in the indices of T-cell immunity can be used to predict the controlled or uncontrolled course of BA. These approaches make it possible to revise the treatment plan for patients in advance and prevent them from losing control of the disease.
Authors and Affiliations
Yu. I. Feshchenko, I. F. Illyinskaya, L. M. Kuryk, L. V. Arefyeva, I. F. Koposova, V. M. Petishkina, A. S. Firsova, O. A. Kanarsky, I. P. Turchyna
Keywords
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- EP ID EP655713
- DOI 10.31655/2307-3373-2019-3-7-16
- Views 101
- Downloads 0
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