Features of encephalopathy diagnosis in patients with portal hypertension syndrome
Journal Title: Гастроентерологія - Year 2017, Vol 51, Issue 4
Abstract
Background. Hepatic encephalopathy is a pathological change in the brain functions of non-inflammatory origin, which is manifested by a syndrome of secondary neurological and cognitive disorders caused by a set of deep metabolic disorders, as a result of acute hepatic insufficiency, chronic liver disease or portosystemic shunting of the blood. The initial stage of encephalopathy does not have clinical neurologic symptoms, but is defined in 20–80 % of patients with liver cirrhosis, and, unlike the final stages, is reversible. The purpose of the study was to evaluate the effectiveness of the number connection test, сritical flicker frequency test and an electroencephalography in the diagnosis of encephalopathy in patients with hepatic and extrahepatic form of portal hypertension. Materials and methods. Syndrome of hepatic encephalopathy was studied in 50 patients with hepatic form of portal hypertension, 30 — with extrahepatic form of portal hypertension and 25 persons without signs of portal hypertension. For the diagnosis, number connection test, сritical flicker frequency test and an electroencephalography were used. Results. A simple-to-use and number connection test made it possible to establish manifestations of hepatic encephalopathy in almost all patients, regardless of the presence of portal hypertension and its form. However, manifestations of hepatic encephalopathy prevailed in patients with hepatic portal hypertension in terms of incidence and severity. Critical flicker frequency test allowed to diagnose minimal hepatic encephalopathy in 96.0 % of patients with hepatic portal hypertension and 60.0 % of patients with extrahepatic portal hypertension. The electroencephalography established the presence of hepatic encephalopathy in 60.0 % of patients with hepatic portal hypertension, 50.0 % — with extrahepatic portal hypertension and 12.0 % of individuals without portal hypertension. Conclusions. Comparison of the effectiveness of diagnostic tests showed that am easy to use and accessible number connection test is most effective, however, other tests also have benefits in the clinical evaluation of hepatic encephalopathy in patients with portal hypertension.
Authors and Affiliations
Yu. M. Stepanov, N. V. Chaliy, S. L. Меlanich
Keywords
Related Articles
- EP ID EP249363
- DOI 10.22141/2308-2097.51.4.2017.119291
- Views 72
- Downloads 0
Resistin as a Marker of Liver Function Disorder in Combined Course of Nonalcoholic Fatty Liver Disease and Type 2 Diabetes Mellitus
The objective of the study — to assess the correlation between resistin and indexes of the functional state of the liver in patients with non-alcoholic fatty liver disease (NAFLD), type 2 diabetes mellitus (DM) and with...
Diagnostic Value of Serum Markers of Liver Fibrosis in Patients with HCV-Infection
In the paper we consider the diagnostic possibilities of the use of serum markers of liver fibrosis in patients with chronic HCV-infection. The definition of special tests (AAR, APRI, Forns’ score, FibroIndex, FIB-4, MDA...
Insulin Resistance, Its Role in the Development of Nonalcoholic Fatty Liver Disease in Patients with Metabolic Syndrome, Ways of Correction
The article presents data on the role of the liver in carbohydrate and lipid metabolism, describes glucose metabolism features in insulin resistance and the role of glucokinase pathways of glucose uptake in the hepatocyt...
Parameters of 24-hour pH-metry and Their Relationship with Clinical and Endoscopic Manifestations of GERD in Patients with its Combination with Diabetes Mellitus Type 2
The article presents our own data on the studying clinical features, parameters of 24-hour pH-metry of the esophagus, endoscopic picture in patients with combination of GERD and diabetes mellitus type 2.
Prognostication of Efficiency of Treating Alcoholic Hepatocirrhosis
To create a prognostic table of efficiency of treating alcoholic hepatocirrhosis we had analyzed 21 indices of laboratory researches. An integral estimation — a sum of points over 15 was used for prognostication of effic...