Features of lymphocyte phenotyping in patients with activated recurrent herpetic infection of the first/second type and reproductive system disorders
Journal Title: Міжнародний ендокринологічний журнал - Year 2017, Vol 13, Issue 1
Abstract
The aim of the study was an analysis of the features of changes in lymphocyte subpopulation according to the data of immunography in patients with a recrudescent herpetic infection and reproductive violations. Materials and methods. The peculiarities of lymphocyte phenotyping were studied in 120 patients with activated recurrent herpetic infection of the first/second type (herpes simplex virus (HSV) 1/2), among whom 63 patients were diagnosed with infertility. Results. An increase in the level of killer cells was detected: CD16+/56+ (NK-cells) — in moderately recurrent infection (1–5 relapses within one year) and CD3+/8+ (T-suppressor/killer cells) — in frequently recurrent infection (6 or more episodes during the year). Conclusions. In infertile patients with recurrent HSV 1/2 infection, there has been observed a deficit of cells with suppressive activity: CD4+CD25+CD127– (regulatory T-cells) lymphocytes and CD3+/8+ (T-suppressor/killer cells) lymphocytes.
Authors and Affiliations
T. V. Shmyga, V. Yu. Gayevska
Keywords
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- EP ID EP176195
- DOI 10.22141/2224-0721.13.1.2017.96759
- Views 67
- Downloads 0
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