Hepatic venous pressure gradient measurement in pre-primary and primary prophylaxis of variceal hemorrhage

Pharmacological therapy of portal hypertensión can be accomplished according to different objectives. Among them, pre-primary prophylaxis aims to avoid / delay esophageal varices development while the target of primary p...

Effects of interleukin-4 and interleukin-12B gene polymorphisms on hepatitis B virus vaccination

Approximately 10% of individuals do not respond to hepatitis B virus (HBV) vaccination, i.e. non-responders (NRs). We aimed to investigate the association of interleukin (IL)-4 and IL-12B gene polymorphisms with respons...

Conversion to mycophenolate mofetil monotherapy in liver recipients: Calcineurin inhibitor levels are key

The use of calcineurin inhibitors (CNI) after liver transplantation is associated with post-transplant nephrotoxicity. Conversion to mycophenolate mofetil (MMF) monotherapy improves renal function, but is related to gra...

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Liver-specific case fatality due to chronic hepatitis C virus infection: a systematic review

Despite reports that mortality is increasing, overall case fatality due to hepatitis C virus (HCV) is thought to be low. Given the variability in published rates, we aimed to synthesize estimates of liver-specific case f...