Fecal Tumor M2-Pyruvate Kinase ™ (ScheBo Test) for Colorectal Cancer Detection in Adult Egyptians
Journal Title: IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS) - Year 2017, Vol 12, Issue 3
Abstract
Introduction: Colorectal cancer (CRC) represents the 3rd most common tumor worldwide and the 6th in Egypt. It is still burdened by significant morbidity and mortality despite several therapeutic improvements. A gold standard for early detection and non invasive diagnosis is lacking. Aim was to assess faecal tumor M2-PK™ (ScheBo test) for detection of CRC.ln Adult Egyptians Methods: This cross-sectional, case-control study was carried out on 66 subjects. The cases group comprised 46 consecutive treatment- naïve patients with sporadic CRC proved by colonoscopy, histopathology and abdominal computed tomography which all together helped in tumor staging with TNM and Duke's staging systems. Twenty apparently healthy subjects (without CRC and with normal colonoscopy) served as the control group (age and sex matching the cases group). Faecal tumor M2-PK™ (ScheBo test) was assessed in all the study subjects. Results: Cases were 24 males and 22 females with a mean age of 50.6 ys and the range was 22-81ys . Age ditribution showed 12 cases (26%) below 40 and 50% above 50 ys . Bleeding per rectum was the main presenting symptom (39%) followed by recent onset constipation (34.8%) in the studied cases. Rectal lesions were found during colonoscopy in 47.8% of cases while colonic lesions were found in 52.2%. Mass was the most encountered gross pathology (in 67.4%, 31 cases) followed by ulcer (in 28.3%, 13 cases) and stricture (in 4.3%, 2 cases). Adenocarcinoma was the commonest type (76.1 %, 35 cases) followed by mucinous adenocarcinoma (15.2 %, 7 cases). The fecal levels of tumor M2-PK were significantly higher (P<0.001) in cases compared to the control (35.66 ± 17.32 and 2.74 ± 4.36 U/ml, respectively). Fecal tumor M2-PK levels showed a significant positive correlation with both TNM and Duke’s stages (p˂0.05), while no significant correlation was found with age and sex. Applying ROC curve, at a cut-off value of 3.9 U/ml, fecal Tumor M2- PK was 97.8% sensitive and 85% specific for detection of CRC with AUROC = 0.96. Conclusion: Fecal tumor M2-PK was a sensitive and specific marker for detection of CRC at values ≥ 3.9 U/ml and positively correlated with the tumour grade and stage.
Authors and Affiliations
Amany Helmy Lashin,, Ebada Mohammad Said, Zeiad Samir Gad, Hesham Ali Issa, Rania Zakria Aamer 3, Abdelmoneam Ahmed, Mahmoud Abd El Aty Mohamed, Sheref M. El-Taher
Keywords
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