Fibre Diet for Antipsychotic induced Hyperlipidemia: A review
Journal Title: Scholars Academic Journal of Pharmacy - Year 2014, Vol 3, Issue 6
Abstract
The Dietary fibers are known for their cholesterol lowering effect. Dietary fibers are found in all plant based foods.. Soluble fibers pulls in water to form a gel in the digestive tract. This slows digestion, so that stomach and intestine don’t absorb as much of some nutrients, like starch and sugar. Insoluble fiber can be found in the peels of fruits such as apples, blueberries and grapes. It acts as a natural laxative that speeds the passage of foods through the stomach and gives stool its bulk and helps it move quickly through the gastrointestinal tract. Dietary and pharmacological reduction in total and LDL cholesterol decreases the risk of coronary diseases and dietary intervention is the desirable approach. Antipsychotic medication shows some side effects generally weight gain, high cholesterol level and may increase in risk of diabetes, risk of heart disease, stroke and diabetes and common side effects are blurred vision, dry mouth, drowsiness muscle spasm or tremors. To control over these side effect of increased level of cholesterol lipid profile in the blood, soluble and insoluble fiber diets are administered which decreased the lipid level in the body. Fibers like guar gum has been found to be associated with a 10% reduction in apetite and increase in the feeling of satiety. Fiber reduces cholesterol by multiple mechanisms, namely, interruption of enterohepatic circulation of the bile acids with enhanced bile seceretion, and inhibition of cholesterol absorbtion leading to increased excretion of neutral sterols; additionally guar may entrap fat micelles thereby impending fat absorbtion. The present study highlights about the effect of soluble and insoluble fiber diet on atypical antipsychotic agents induced hyperlipidemia. Keywords: Laxative, Total cholesterol, LDL cholesterol, Coronary disease, Drowsiness, Tremors, Postprandial glycemia, Insulinaemia, Enterrohepatic circulation, Cholestrol absorbtion, Neutral sterol
Authors and Affiliations
Goswami Nupur, Das Sanjita ,, Diksha ,
Keywords
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