Fibromyalgia syndrome: Unraveling the mystery
Journal Title: IP International Journal of Orthopaedic Rheumatology - Year 2016, Vol 2, Issue 2
Abstract
Fibromyalgia (FM) is a common chronic widespread pain disorder. Understanding this disease has increased substantially in recent years with extensive research. Neurochemical imbalances in the central nervous system are associated with central amplification of pain perception characterized by allodynia and hyperalgesia. Despite this increased awareness and understanding, FM remains undiagnosed in an estimated 75% of people with the disorder. Fibromyalgia is a disorder of pain processing. Evidence suggests that both the ascending and descending pain pathways operate abnormally, resulting in central amplification of pain signals, analogous to the “volume control setting” being turned up too high. Patients with FM also exhibit changes in the levels of neurotransmitters that cause augmented central nervous system pain processing; levels of several neurotransmitters that facilitate pain transmission are elevated in the cerebrospinal fluid and brain, and levels of several neurotransmitters known to inhibit pain transmission are decreased. Pharmacological agents that act centrally in ascending and or descending pain processing pathways, such as medications with approved indications for FM, are effective in many patients of FM as well as other conditions involving central pain amplification.
Authors and Affiliations
Shiva Shankar Jha Shiva Shankar Jha
Keywords
Related Articles
- EP ID EP242894
- DOI -
- Views 106
- Downloads 0
Journal of Indian Orthopaedic Rheumatology Association; July-December 2016:2(2); 81-85 81 A study of the relationship of anthropometric measurements with bone Mineral density in population in and around Bhopal
Objective: To collect the data of anthropometric measurement around District Bhopal, M.P and find out the relationship between BMI & BMD. Method: This was a cross sectional study in which anthropometric data of 489 perso...
Compound palmar ganglion associated with tuberculous arthritis of wrist causing compression of the median and ulnar nerves: Management
50 years old male agricultural labourer presented with 5 months history of pain and swelling of the right wrist and hand There was no history of any previous trauma or other constitutional symptoms Patient had associated...
Fibrodysplasia ossificans progressiva – A rare case
Fibrodysplasia Ossificans Progressiva FOP also known as Myositis Ossificans Progressiva is a very rare and disabling genetic condition characterized by congenital malformation of the great toes with hallux valgus and pro...
Assessment of the relationship of developmental milestones and pattern of primary teeth eruption among Saudi children –a cross sectional study
Introduction: The time of eruption of deciduous teeth is an important concern for the parents, which shows a significant difference of timing in the population of Saudi Arabia. However, there are only few studies which a...
Cytokines in osteoporosis and steroid induced osteoporosis
WHO (1993) has defined osteoporosis “disease characterized by low bone mass and microarchitectural deterioration of bone tissue, leading to enhanced bone fragility and a consequent increase in fracture risk”. (1) Osteopo...