Forced degradation of metronidazole, oxytetracycline and furazolidone studies using High Performance Liquid Chromatography
Journal Title: Medicamentul Veterinar / Veterinary Drug - Year 2014, Vol 8, Issue 1
Abstract
The study describes the development of a HPLC -DAD method for the estimation of oxytetracycline and furazolidone in Enteroguard M - powder. The proposed method utilizes a Betasil C 18 column, (4.6 x 250 mm, 5 µm), at 300 C, optimum mobile phase consisted of 40 mM phosphate buffer (pH=7.5): methanol in gradient elution. The flow rate was optimized to 1mL/min and the detection was carried at 254 nm. The drug substance was exposed to temperature, light, oxidants, acid and basic hydrolysis, and the resultant samples were analyzed by the proposed method.
Authors and Affiliations
Violeta Tauber (Giugiu), Viorica Chiurciu
Keywords
Related Articles
- EP ID EP131631
- DOI -
- Views 164
- Downloads 0
The efficacy of the product Albendazole 10% of gastrointestinal nematode parasitism in sheep tested
Trichostrongylids are helminths of ruminants, located gastro-intestinally. The disease generated by them is clinically manifested mainly by: diarrhea, weight loss, anemia and cachexia. They are produced by parasites belo...
Genul Staphilococcus – Mic ghid practic
In prezentul referat destinat educatiei continue a specialistilor din domeniu este prezentat un gen bacterian important pentru sănătatea omului si a animalelor. Autorii prezintă în două capitole, întro manieră didactică,...
Elemente de terapie alternativă și complementară în medicina veterinară
No abstract
Pollutants impact bioassay from waters and soils in Banat region
Analyses of water and soil samples by chemical methods identified the quantities of chlorides, nitrates and phosphates by comparison with the maximum limits of law. Acute toxicity tests on zebra fish embryos is an altern...
Simultaneous determination of related substances of oxytetracycline in pharmaceutical semi solid form by Hight Performace Liquid Chromatography
Simultaneous determination of oxytetracycline, 4-epioxytetracycline, alpha-apooxytetracycline, tetracycline, betta-apooxytetracycline on C18 columns has been accomplished using a high performance liquid chromatographic m...