Forgotten Circadian Aspect in miRNAs Oriented Research
Journal Title: Journal of RNA and Genomics - Year 2017, Vol 13, Issue 1
Abstract
Until today several tens of classes of small non-coding RNAs have been discovered. Among them a class of miRNAs represents one of the most abundant (and still growing) groups with thousands of members. miRNAs are expressed in a tissue specific manner, play a number of regulatory roles in the cell and can be excreted by the cell to the extracellular space and/ or circulation (Hammond, 2015; Voglova et al, 2016). miRNAs have attracted a growing interest with notable acceleration after 2005. Moreover, according to Scopus, March, 2017, there are more than 39,000 registered patents or submitted patent applications focused on miRNA. miRNA oriented research is so intensive mainly because of a robust influence of miRNA on transcriptome regulation. This knowledge opens a possibility to manipulate miRNA regulated expression in order to achieve desired changes via artificially developed oligos. The above mentioned technology is known as RNA interference (RNAi). This approach has already resulted in first clinical studies (Lam et al, 2015). The second line of investigation is aimed at mechanisms determining which miRNAs are excreted into the extracellular space, whether they can play a role as signaling molecules and how specific their composition is in regards to tissue and/or cell state (Lu et al, 2005). Recently, it seems to be accepted that miRNA spectrum in plasma corresponds well with many specific diseases and commercial pharmacological companies are already developing panels of miRNAs to be tested in medical practice (Zampetaki et al, 2012).
Authors and Affiliations
Iveta Herichova
Keywords
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