FORMULATION AND CHARACTERIZATION OF ETHOSOMES BEARING VANCOMYCIN HYDROCHLORIDE FOR TRANSDERMAL DELIVERY
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2014, Vol 6, Issue 11
Abstract
Objectives: To investigate and evaluate the transdermal delivery of ethosomes bearing vancomycin hydrochloride, a glycopeptide antibiotic with a relatively high molecular weight (1485.7Da).Methods: Vancomycin loaded ethosomes were prepared by cold method technique and characterized for vesicular shape, vesicular size, entrapment efficiency, zeta potential, in vitro drug permeation, microbiological assay against methicillin resistant Staphylococcusaureus (MRSA) and stability.Results: Microscopic examinations suggested ethosomes as unilamellar spherical vesicles. Vesicle size, entrapment efficiency and zeta potential values were depending on concentration of membrane components. Ethosomal formula having 1% phospholipid, 45% ethanol and 10% propylene glycol (F13) showed the smallest mean particle size (71.60nm±17.6) and highest transdermal flux (414.7 µg/cm2. hr) across hairless rat skin which was 72.67 times drug solution. The results obtained from microbiological assay suggested that the minimum inhibitory concentration (MIC) is affected by surface charge of ethosomes. The optimized formula on storage at 4°C for 90 days retained 89.82%±1.00 of initial drug content.Conclusions: The results collectively suggest that ethosomes are efficient carrier for transdermal delivery of vancomycin hydrochloride.
Authors and Affiliations
Magdy I. Mohammed, Amna M. A. Makky, Menna Abdellatif
Keywords
Related Articles
- EP ID EP579287
- DOI -
- Views 82
- Downloads 0
ESTIMATION OF ALKALOIDS AND PHENOLICS OF FIVE EDIBLE CUCURBITACEOUS PLANTS AND THEIR ANTIBACTERIAL ACTIVITY
Objective: Objective of the present work was qualitative and quantitative estimation of alkaloids and phenolics of five edible cucurbitaceous plants and to evaluate their antibacterial activity against some human pathoge...
LINEAR ASSESSMENT OF CEREBRAL AUTOREGULATION IN IDIOPATHIC PARKINSON'S DISEASE
Parkinson’s disease cases have been on the rise in the recent years, which promoted several different researches into the disorder. However, there hasn’t much research been done in the non-motor aspects of the diseas...
IN SILICO ANALYSIS OF INHIBITOR AND SUBSTRATE BINDING SITE OF SERRAPEPTIDASE FROM SERRATIA MARCESCENS MTCC 8708
Objective: Serrapeptidase is a therapeutic enzyme broadly used as an anti-inflammatory drug to treat inflammatory diseases like arthritis, bronchitis, fibrocystic breast disease and sinusitis. The objective of present st...
HYPOGLYCEMIC AND HYPOLIPIDEMIC EFFECTS OF ANNONA MURICATA L. LEAF ETHANOL EXTRACT
Objective: The aim of this study was to investigate hypoglycemic and hypolipidemic effects of Annona muricata leaf ethanol extract. This study also investigated phytochemical analysis of the extract and improvement in th...
EVOLUTION OF NANOTECH ASSISTED PCR DIAGNOSIS OF MYCOBACTERIUM TUBERCULOSIS AND ITS ASSESSMENT WITH CONVENTIONAL METHODS
Objective: This study was focused on assessment and performance of conventional and nanotech assisted methods for detection of Mycobacterium tuberculosis. Tuberculosis (TB) still leftovers one of the top ten causes of de...