FORMULATION AND CHARACTERIZATION OF TPP CROSS-LINKED CHITOSAN MICROSPHERES LOADED WITH LORNOXICAM
Journal Title: Journal of Biomedical and Pharmaceutical Research - Year 2014, Vol 3, Issue 3
Abstract
In the present study, tripolyphosphate (TPP) cross-linked chitosan microspheres loaded with lornoxicam were prepared by ionic gelation technique. The effect of formulation and process variables on physicochemical properties of microspheres was investigated. FT-IR, DSC and XRD studies revealed the absence of any chemical interactions between the drug and excipients used. Scanning electron microscope images revealed that the prepared microspheres were discrete, broadly spherical with rough surface characteristics. The size of the microspheres was in the range of 615.32 ± 3.21μm to 855.14 ± 2.83μm which increased with increase in core: coat ratio; reduced when the pH of the TPP medium was changed from its original alkaline to acidic and also with increased extent of cross-linking. Percentage encapsulation efficiency was found to be within 56.33 ± 1.8 to 96.59 ± 3.62 and it was largely dependent on core: coat ratio, pH of the TPP medium and extent of cross-linking. Higher drug release was observed for the microspheres prepared at lower core: coat ratios and also for those prepared at the original pH of dispersion medium. On the other hand, more controlled drug release was observed with the microspheres containing higher polymeric levels prepared in the acidic medium. The drug release was also reduced with higher cross-linking conditions. Non-Fickian diffusion controlled drug release mechanism was observed for all the microspheres except those prepared at higher cross-linking conditions, which exhibited zero order release kinetics. Overall, formulation and process variables have significantly affected the physicochemical properties of the prepared microspheres.
Authors and Affiliations
Shrishailgouda S Patil*| Department of Pharmaceutics, N.E.T Pharmacy College, Raichur, Karnataka, India, V Ram Mohan Gupta| Department of Pharmaceutics, Pulla Reddy Institute of Pharmacy, Dommadugu, Dundigal, Hyderabad, Andhra Pradesh, India, K Srikanth Gupta| Department of Pharmaceutics, Pulla Reddy Institute of Pharmacy, Dommadugu, Dundigal, Hyderabad, Andhra Pradesh, India, H Doddayya| Department of Pharmaceutics, N.E.T Pharmacy College, Raichur, Karnataka, India
Keywords
Related Articles
- EP ID EP2527
- DOI -
- Views 411
- Downloads 20
NASAL CARRIAGE OF METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS AMONG MEDICAL STAFF AT OMDURMAN TEACHING HOSPITAL
Background: methicillin-resistant Staphylococcus aureus( MRSA) is a strain of Staphylococcus aureus which is resistant to methicillin and other antibiotics. Staphylococcus aureus is an organism that colonizes mainly in t...
An Approach Based on Advantages over Conventional System
The convenience of administration and improved patient compliance are important in the design of oral drug delivery system which remains the preferred route of drug delivery inspite of various disadvantages. Oral deliver...
THE POSSIBLE PROPHYLACTIC EFFECT OF EGYPTIAN MORINGA OLEIFERA SEED OIL AS ANTI-ULCER ACTIVITY AND ANTI-INFLAMMATORY IN RATS.
Moringa oleifera Lam. is the multipurpose tree (therapeutic potential and nutritive value). In this work, authors focused on importance of Moringa oleifera seed oil (MSO) as antioxidant, anti-inflammatory and antiulcer....
ANALYTICAL METHOD DEVELOPMENT AND VALIDATION OF A SIMULTANEOUS DETERMINATION OF CITICOLINE AND PIRACETAM AT SINGLE WAVELENGTH
A simple, selective, rapid, precise, accurate, sensitive and robust RP-HPLC method has been developed and validated for the determination of citicoline and piracetam in tablet dosage form. The method was carried out on a...
Pharmacognostic and phytochemical studies on Parthenium hysterophorus L.
From last few decades there is an increased use of herbal medicines all over the world and now there is need to study herbal drugs on scientific basis to develop their monographs. The present research work was an attempt...