FORMULATION AND EVALUATION OF BILAYER TABLET OF CONVENTIONAL RELEASE PARACETAMOL AND MODIFIED RELEASE DICLOFENAC SODIUM
Journal Title: Indian Journal of Research in Pharmacy and Biotechnology - Year 2013, Vol 1, Issue 5
Abstract
The present study deals with formulation and evaluation of bilayer tablet of paracetamol and diclofenac sodium to provide control over release of drug and to maintain the drug concentration. The major ingredients are paracetamol granules and diclofenac sodium granules and were prepared separately by wet granulation method. Paracetamol, PEG6000 and intragranular fraction granules were cooled and blended with microcrystalline cellulose, croscarmellose, Cab-O-Sil and magnesium stearate and mixture of diclofenac sodium and HPMC K4M were granulated using water and isopropyl alcohol. The wet mass is passed through a 20# sieve and dried. The granules of optimized batch of paracetamol and diclofenac sodium were compressed to obtain bi-layer tablet. The tablets were evaluated for percentage friability, crushing strength and in-vitro drug release. Totally 9 formulations for paracetamol and 6 formulations of diclofenac were prepared and studied for their various precompression and postcompression parameters. The formulation F9 for paracetamol showed in-vitro drug release of 93.09% and exhibited satisfactory results in all parameters and subjected to stability studies. And the formulation F6 showed in-vitro drug release of 71.68% and exhibited satisfactory results and was subjected to stability studies. Thus formulation F9 for paracetamol and F6 for Diclofenac was found to be successful as immediate release and extended release bi-layer tablet and can be manufactured with reproducible characteristics from batch to batch.
Authors and Affiliations
Indhumathi D, Mastan Vali Sheik, Priyadharshini N, Damodharan N
Keywords
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