FORMULATION AND EVALUATION OF CIPROFLOXACIN-COCKLE SHELLS DERIVED CALCIUM CARBONATE ARAGONITE NANOPARTICLES PHYSICOCHEMICAL PROPERTIES MEDIATED IN VITRO BACTERICIDAL ACTIVITY IN SALMONELLA TYPHIMURIUM
Journal Title: European Journal of Pharmaceutical and Medical Research - Year 2017, Vol 4, Issue 4
Abstract
Since the use of classical antibiotics in the management of resistant bacterial infections requires high dosage and regular administration for a lengthy duration, the enhanced delivery system that will ensure sustained release of antibiotic to the Site of action is important. We synthesized and formulated ciprofloxacin-cockle shell derived calcium carbonate aragonite nanoparticles (C-CSCCAN), appropriately analysed its physicochemical properties mediated antibacterial activity in Salmonella Typhimurium. The size of the formulated nanoparticles were in the range of 13.94 and 23.95 nm and Zeta potential was optimally negative. Diffraction pattern by X-ray powder diffraction (XRD) revealed strong crystallizations in all the formulations. Fourier-transform (FT-IR) spectra displayed evidence of interactions between the drug and nanoparticles at the molecular level and no change in peaks position was observed prior to and after the synthesis of the nanoparticles. Higher encapsulation (99.5) and loading capacity (5.9%) were attained at ciprofloxacin to nanoparticles ratio 1:17. No burst effect but a sustained drug release was observed from the formulation. C-CSCCAN suspension exhibited higher antibacterial activity than free ciprofloxacin. It was concluded that physicochemical properties of CSCCAN enhanced susceptibility of Salmonella Typhimurium, which could potentially improve the clinical efficacy of ciprofloxacin.
Authors and Affiliations
Dr. Sani Ibn Yakubu
Keywords
Related Articles
- EP ID EP628997
- DOI -
- Views 162
- Downloads 0
A CASE STUDY AND CLINICAL LITERATURE REVIEW OF FOURNIER’S GANGRENE, DEMONSTRATING RESOLUTION WITH ANTIBIOTIC THERAPY AND IN THE ABSENCE OF SURGICAL OR ANY OTHER INTERVENTION
This case report describes a lesser common condition, namely Fournier's gangrene, involving a rapidly advancing, necrotising infection of deep tissues, starting from the perineal area with spread along fascial planes. Th...
PROGNOSTIC SIGNIFICANCE OF SERUM ALBUMIN IN ACUTE ISCHEMIC STROKE
Objective: Evaluating the prognostic significance of serum albumin in acute ischemic brain stroke (AIS) in comparison to NIH stroke scale and modified Rankin score. Study Design: Observational study. Study setting & Dura...
THIOBENCARB DECREASES TESTICULAR GERM CELL PROLIFERATION, INHIBITS SPERMATOGENESIS AND INCREASES APOPTOSIS: HISTOLOGICAL AND IMMUNOHISTOCHEMICAL ASSESSMENTS
Background: Herbicides were found to induce harmful health effects as oxidative stress, reproductive disorders and histopathological alterations in vital organs. Thiobencarb is heavily used in rice cultivation in Egypt....
CAUDAL VERSUS INTRAVENOUS KETAMINE FOR SUPPLEMENTATION OF ANALGESIA IN PEDIATRICS UNDERGOING HYPOSPADIAS REPAIR: A COMPARATIVE STUDY
Background: Different additives have been reported to prolong the duration of caudal anesthesia in pediatrics. Although these drugs successfully increased the duration of the block. Ketamine has been found to effectively...
EFFECT OF TARTRAZINE ORALLY ADMINISTERED ON SOME ATHEROGENIC INDICES OF ALBINO RATS
In this study the effect of tatrazine on some atherogenic indices of albino rats were evaluated. Thirty (30) rats weighing approximately 0.14kg were used. The rats were divided into five (5) groups of six (6) rats per gr...