FORMULATION AND EVALUATION OF DISPERSED PERMETHRIN PRONIOSOMES IN POWDER AND MICROEMULSION-BASED HYDROGEL BASES FOR THE TREATMENT OF SCABIES
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2016, Vol 8, Issue 1
Abstract
Objective: This study is aimed to encapsulation of permethrin in proniosomes and formulation and evaluation of dispersed permethrin in powder and micro emulsion-based hydrogel bases.Methods: Permethrin proniosomes were prepared by modified slurry method using Brij 97, cholesterol, aerosil 200 and drug in different weight ratios, and using two different solvents. The prepared proniosomes were characterized for particle size, shape, flow characteristics, entrapment efficiency.Results: The studies demonstrated successful preparation of permethrin proniosomes. The effect of using different weight ratios of Drug: Brij 97: Cholesterol and different solvents on entrapment efficiency were studied. The best proniosomes showed entrapment efficiency percent of 55.58%±1.451 for permethrin and zero residual solvents. Such formula was incorporated in a topical powder and micro emulsion-based hydrogel basis and evaluated through particle size, drug content, stability, and clinical trials for efficacy on sarcoptic mite infestation in sheep and rabbits.Conclusion: Permethrin 5 % micro emulsion-based hydrogel proved to be homogenous, stable, and clinically effective, compared with the topical powder that was unstable under accelerated stability conditions.
Authors and Affiliations
Alia Badawi, Mohamed A. Elnabarawi, Randa Tag A. Elrehem, Bassem A. Fayed
Keywords
Related Articles
- EP ID EP577944
- DOI -
- Views 80
- Downloads 0
HYPOGLYCEMIC EFFECT OF OLIVE MILL WASTEWATER IN MICE INVOLVES THE SGLT-1 TRANSPORTER
Withdraw
OPTIMIZATION OF PROCESS PARAMETERS FOR THE PRODUCTION OF ANTIBACTERIAL COMPOUND BY A NEWLY ISOLATED NOCARDIA CYRIACIGEORGICA, KD-15 STRAIN FROM KAZIRANGA NATIONAL PARK OF NORTH EAST INDIA
Objective: An attempt has been made to evaluate the optimal cultural conditions for obtaining high yields of bioactive metabolites.Methods: A strain of actinobacteria was isolated from the soil sample of Kaziranga Nation...
DEVELOPMENT AND VALIDATION OF RP-HPLC METHOD FOR SIMULTANEOUS DETERMINATION OF CLOPAMIDE, DIHYDROERGOCRISTINE MESYLATE AND RESERPINE IN TABLETS
Objective: To develop a new, rapid, precise and sensitive RP-HPLC method for the simultaneous determination of Clopamide (CPM), Dihydroergocristine mesylate (DHECM) and Reserpine (RSP) in tablets.Methods: Caffeine (CAFF)...
INVESTIGATION OF EFFECT OF PHOSPHOLIPIDS ON PHYSICAL AND FUNCTIONAL CHARACTERIZATION OF PACLITAXEL LIPOSOMES
Objective: Aim of the present investigation was to determine the effect of various synthetic grades of phospholipids on paclitaxel liposomes (PTL).Methods: The PTL formulations using various grades of phospholipids were...
IMPROVEMENT OF GLICLAZIDE’S DISSOLUTION RATE BY USING SURFACE SOLID DISPERSION WITH AVICEL PH 101
Objective: The aim of this study was to improve the dissolution rate of gliclazide by developing a surface solid dispersion (SSD) with Avicel PH 101 as a carrier.Methods: Solid dispersions of gliclazide were prepared, wi...