FORMULATION AND EVALUATION OF FAST DISSOLVING TABLETS OF OFLOXACIN BY DIRECT COMPRESSION METHOD
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2013, Vol 4, Issue 11
Abstract
Ofloxacin is a broad-spectrum, synthetic fluoroquinolones antibacterial agent for oral administration. The bioavailability of ofloxacin in the tablet formulation is approximately 98 %. It is extremely bitter in taste, water insoluble drug. It is used to treat variety of infections. The purpose of the present research work was to formulate and evaluate the fast dissolving tablets of ofloxacin by direct compression method using different super disintegrants like PGS (pre gelatinized starch), SSG (sodium starch glycolate), PVPP (ploy vinyl poly pyrrolidone) in different concentrations 5 %, 7.5 %, 10 %. FT-IRspectroscopy was used to investigate the physical characteristics of the complex. The blend was evaluated for angle of repose, bulk density, tapped density, carr’s index, hausner ratio. The tablets were evaluated for weight variation, hardness, friability, disintegration time, water absorption ratio, wetting time, drug content uniformity and in vitro dissolution. Tablet formulated with 10 % (F9) of PVPP showed low disintegration time (8 2), wetting time (4.3 0.3), friability than the other batches. The % cumulative release of drug from tablet (F9) was found to be more than 87 % within 10 minutes. It was concluded from the study that ofloxacin may improve patient compliance especially pediatric and geriatric patients and increase the efficacy of drug for treating infections.
Authors and Affiliations
Shivaramakrishna Baddam, Sreedhar Bandari, G. B Chaithanya
Keywords
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- EP ID EP99101
- DOI 10.7897/2230-8407.041118
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