FORMULATION AND EVALUATION OF FAST DISSOLVING TABLETS OF VALDECOXIB
Journal Title: Journal of Biomedical and Pharmaceutical Research - Year 2018, Vol 7, Issue 6
Abstract
Valdecoxib is a selective COX- II inhibitor with anti – inflammatory, analgesic and antipyretic properties. The poor aqueous solubility of the drug leads to variable dissolution rates. In the present study an attempt has been made to prepare fast dissolving tablets of Valdecoxib in the oral cavity with enhanced dissolution rate. The fast dissolving tablets of Valdecoxib was prepared with some carriers (polymers) and super disintegrants such as Polyvinyl Pyrrolidone (PVP), Sodium Carboxy Methyl Cellulose (SCMC), Crospovidone NF and β – Cyclodextrin. The above mentioned all carriers and superdisintegrants were taken in different proportions of 5, 10, and 15%. All the formulations of the fast dissolving tablets of Valdecoxib were prepared by direct compression technique. The blend was examined for Angle of repose, Bulk density, Compressibility index and Hausner’s ratio. The prepared tablets were evaluated for hardness, drug content uniformity, friability, disintegration time and dissolution rate. An effective pleasant testing formulation released 99.88% drug within 10 minutes. The prepared formulations drug release was found to be comparable with the marketed dispersible tablets. Keywords: Fast dissolving tablets, Super-disintegrants, Valdecoxib, Crosspovidone, Sodium Carboxy Methyl Cellulose.
Authors and Affiliations
K Kareemuddin Ansari
Keywords
Related Articles
- EP ID EP487318
- DOI -
- Views 176
- Downloads 0
FORMULATION AND EVALUATION OF FAST DISSOLVING ORAL FILMS OF FLUVASTATIN SODIUM BY USING TASTE MASKING TECHNIQUES
Fluvastatin sodium, a HMG-COA reductase inhibitor has shorter half life (1.2). It undergoes extensive first pass metabolism, frequent dosing is required in case of conventional dosage form. It is an bitter drug so an att...
Immunoprecipitation of 11 ZN fingers Domains, CTCF and BORIS to Multifunctional Y-box DNA/RNA-binding factor, YB-1 in Glioma-RGBM
CCCTC binding factor (CTCF) is a unique highly conserved and ubiquitously expressed 11 zinc finger (ZF) transcriptional factor with multiple target site. It is able to bind to various target sequences to perform differen...
Drug Utilization Evaluation of Proton Pump Inhibitors in General Medicine Department of a Tertiary Care Teaching Hospital
Proton pump inhibitors (PPIs), antagonists of H+K+ ATPase, have been found as the most efficacious inhibitors of the gastric acid secretion. Prescribing PPIs is on the rise owing to polypharmacy and multiple co-morbid co...
HISTOPATHOLOGICAL CHANGES IN ADHATODA VASICA TREATED MICE STOMACH AFTER GAMMA-IRRADIATION.
In the present study, Adhatoda vasica extract administered and radiation induced changes in the stomach of Swiss Albino male mice were studied. Animals were divided into four groups: Group I containing normal mice served...
An Overview of Asthma and its treatment
Asthma is a disorder characterized by chronic airway inflammation, airway hypersensitivity to a variety of stimuli, and airway obstruction. It is at least partially reversible, either spontaneously or with treatment. Ast...