FORMULATION AND EVALUATION OF FLOATING MATRIX TABLETS OF FAMOTIDINE USING NATURAL POLYMERS
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2011, Vol 2, Issue 6
Abstract
In the present investigation effervescent floating matrix tablets of famotidine are formulated to achieve gastric retention for a period of 8 to 10 hrs. Famotidine is H2 receptor antagonist widely prescribed in gastric ulcer, Duodenal ulcer, Zollinger Ellison syndrome & Gastro-esophageal reflux disease. Famotidine has low oral bioavailability of 35% & short biological half life of 2 – 3 hrs. This favors development of sustained release dosage form. Besides this, it is primarily absorbed from stomach. Local delivery increase stomach wall receptor site bioavailability and increase efficacy of drug to reduce acid secretion. Hence the principle of Floating drug delivery system was applied to improve systemic as well as local drug delivery. Natural polysaccharides such as xanthan gum and chitosan were used to achieve sustained release of the drug. Thus it can be concluded that floating matrix famotidine tablets so formulated achieved desired gastric retention for 8 to 10 hrs and sustained the drug release. Thus one tablet daily is sufficient to reduce gastric acidity as compared to conventional tablets in hyperacidity conditions.
Authors and Affiliations
Leena Jagtap , Seema Swami , Prabha Mali , Pallavi Tripathi , Kishor Deshmukh
Keywords
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