FORMULATION AND EVALUATION OF FLOATING MICROSPHERES OF DIACEREIN BY IONIC GELATION METHOD
Journal Title: World Journal of Pharmaceutical and life sciences - Year 2018, Vol 4, Issue 7
Abstract
Background: Floating microspheres containing Diacerein were prepared by ionotropic gelation technique by using HPMC (K 100 M), and sodium alginate as polymers, sodium bicarbonate as gas generating agent and calcium chloride as cross linking agent. Objective: To formulate a system to remain in the stomach for controlled and predictable period in order to enhance the drug bioavailability. Method: Totally 12 different formulations of Diacerein were prepared by using the above polymers. All formulations were evaluated for percentage yield, particle size, swelling index, entrapment efficiency, floating time and total floating time, Morphology of the microspheres and in-vitro drug release. Results: The percentage yield was found to be in the range of 45.0% to 80.62%.The average particle size was found to be in the range of 816 to 1292.7 μm. % Drug entrapment efficiency of Diacerein floating microspheres ranged from 27 % to 110 %. From the observations the total floating time was high for formulations F7, F8, F9.The swelling index of different formulations from F1 to F12 was found to be from 5 to 40%. The cumulative percent drug release of Optimized formulation F9 was found to be 95.42 % at 180 min. SEM study showed that pores were found on the surface of microspheres with a possible indication that the drug is released by diffusion mechanism. The ideal formulation, F9 followed first order kinetics and kosemeyers-peppas release model and value of "n," is calculated to be 0.7187 indicated that the drug release shows Non-Fickian diffusion. The formulation was stable at the end of 30 days with stability study. Conclusion: The optimized formulation showed good floating for > 3hrs. The formulation was stable at the end of 30 days with stability study.
Authors and Affiliations
Swapna S.
Keywords
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