FORMULATION AND EVALUATION OF FLOATING TABLET OF ECLIPTA ALBA EXTRACT FOR HEPATIC DISORDERS
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2015, Vol 7, Issue 4
Abstract
Objective: The aim of the present study was to design and estimate gastro retentive floating tablet of Eclipta alba extract to increase the efficacy by extending the release of extract. Eclipta alba is reported to be useful in liver ailments and has been shown to possess hepatoprotective activity.Methods: The floating tablet extract of Eclipta alba was prepared by using kollidon SR as floating and release retarding polymer. The effect of various additive excipient was also studied and optimized using 32full factorial design to alter the floating behaviour and extract release from the floating tablet.Results: The polymeric structure of Kollidon® SR possesses appreciable porosity during the compression process. Results of multiple regression analysis show that the amount of stearic acid and lactose has significant influence on Q2, Q6 and Q10.Conclusions: From the desirability function, the levels of the optimized batch were selected as -1 for the X1 and 1 for the X2 which correspond to batch F3 of factorial design. This study can open the avenues for the In-vitro dissolution testing of herbal extracts by simple UV method for the determination of extract release in extended release formulations.Â
Authors and Affiliations
Suresh D Sanja, Kilambi Pundarikakshudu, Moinuddin M Soniwala
Keywords
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