Formulation and Evaluation of Medicated Mouth Paint for Oral Thrush
Journal Title: International Journal of Pharmaceutical Science Invention - Year 2018, Vol 7, Issue 6
Abstract
In the present work is aimed at oral retentive mouth paint preparations were designed and prepared for the effective treatment of oral candidiasis. Voriconazole, a triazole derivative having antifungal activity is chosen as model drug in this study. Voriconazole is used to treat oral candidiasis, which is a common infection in debilated patients, AIDS patients and in persons who administer immunosuppressive drugs. Oral retentive mouth paints containing 1% Voriconazole with different hydrophilic polymers MC, HEC, NaCMC, PEG, glycerol, sodium citrate were formulated and evaluated for physical appearance, pH, drug content, rheological behaviour, spreadability, and FTIR spectral analysis. In vitro drug release studies were carried out at salivary pH 6.4 using cellophane membrane as barrier. Stability studies were carried out on all prepared formulations at ambient temp (RT), 30 ± 1 o C at 65% ± 5% RH, 40 ± 2 o C at 75% ± 5% RH (accelerated temperature) for a span of 3 months and analyzed at different time intervals for drug content, physical appearance, pH, oral retention time and spreadability. All the prepared formulations were found to be stable.
Authors and Affiliations
Hindole Sunil S. , Nagoba Shivappa N, Shaikh Atiya L. , Shaikh Neha M
Keywords
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