FORMULATION AND EVALUATION OF MEFENAMIC ACID SOLID DISPERSIONS USING PEG-4000
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2013, Vol 4, Issue 5
Abstract
Mefenamic acid (MA) solid Dispersions were prepared employing methanol as a common solvent using PEG-4000 as a drug carrier with two different techniques namely, melting method and solvent evaporation in varied ratios. The prepared solid dispersions were evaluated and compared with that of pure drug (mefenamic acid) in respect to the dissolution rate and dissolution efficiency. It is noted that solid dispersions of mefenamic acid showed a remarkable increase in dissolution rate and dissolution efficiency. An increase in the dissolution rate was observed with an increase in PEG-4000 concentration with regarding to solvent evaporation method.Dissolution rate of mefenamic acid was found to beincreased 8.14 folds with mefenamic acid- PEG-4000 solid dispersion (1:2) ratio, in case of solvent evaporation method, and 6.51 folds with mefenamic acid- PEG-4000 solid dispersion (1:1) ratio. PEG-4000 can be used in order to raise the dissolution rates of poorly soluble drugs such as mefenamic acid.
Authors and Affiliations
Jamal Shaik , Saleem Shaik , Naga Pavan Alaparthi , Ajay Kumar, Madhusudhan Punuru
Keywords
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