Formulation and evaluation of mucoadhesive microspheres of roxatidine acetate hydrochloride
Journal Title: International Journal of Allied Medical Sciences and Clinical Research - Year 2016, Vol 4, Issue 3
Abstract
The intention of the present study is to formulate mucoadhesive microspheres containing roxatidine acetate hydrochloride by employing xanthan gum & gum olibanum as mucoadhesive agent and by adapting ionotropic gelation technique. Response Surface Composite design was employed to study the effect of independent variables, polymer concentration (X1), and sodium alginate concentration (X2) on dependent variables mucoadhesion time. The best batch exhibited a high drug entrapment efficiency of 95.01% and a swelling index of 96.23%; percentage mucoadhesion after 10 h was 97.01%. The drug release was also sustained for 12 h. The polymer-to-drug ratio had a more significant effect on the dependent variables. The prepared mucoadhesive microspheres were characterized for various properties like preformulation, flow properties, in vitro mucoadhesion, in vitro drug release, entrapment efficiency and surface properties. The external and internal surface morphological characteristics of mucoadhesive microspheres were investigated using Scanning Electron Microscope (SEM). The formulation which showed better flow properties, in vitro mucoadhesion, in vitro drug release and entrapment efficiency was selected as optimized formulation i.e., formulation MOG4. The in vitro release profiles from optimized formulations were applied on various release kinetic models of drug and suggested that the drug release from microspheres followed non-fickian diffusion. The optimized formulation MOG4 was subjected to stability studies for six months at 400±20C & 75±5%RH as per ICH guidelines and result have not showed any changes in physical parameters, formulation parameters and in vitro release studies.
Authors and Affiliations
SK. Arifa Begum
Keywords
Related Articles
- EP ID EP420071
- DOI -
- Views 61
- Downloads 0
Clinical note on use of povidone iodine in periodontics
Povidone iodine (PVP-iodine) is one of the widely used antiseptics in the field of medicine and surgery but it has not gained significant attention in dentistry. It is one of the most potent antiseptics with a wide range...
Exposure Index and Entrance Surface Dose of ANSI Chest Phantom with Computed Radiography
Background Radiographer shall ensure the radiation safety of the patient. Posteroanterior chest projection is a frequent examination in the radiology unit. Each radiographic projection must have a safe dose that justifie...
The De Ritis (AST/ALT) ratio in alcohol dependence syndrome with and without alcoholic liver disease
Introduction Alcoholism is characterized by an impaired control over drinking, preoccupation with alcohol and use of alcohol despite adverse consequences. Alcohol consumption is associated with a number of changes in cel...
Nutritional supplement for eyes: for prevention & treatment of cataract
Cataract is multifactorial diseases associated with several risk factors and it is responsible for 50% of blindness worldwide. At present, the only remedy for cataract is surgery. However the incidence is so large that t...
Controlled release matrix drug delivery system – a review
Oral controlled release drug delivery system becomes a very promising approach for those drugs that are given orally but having the high dosing frequency and shorter half life. Matrix tablets serves as an important tool...