FORMULATION AND EVALUATION OF NANOSUSPENSION OF ROSUVASTATIN CALCIUM
Journal Title: International Journal of Drug Regulatory Affairs - Year 2013, Vol 1, Issue 3
Abstract
Poor water solubility and slow dissolution rate are issues for majority of upcoming and existing biologically active compounds. The aim of present work was to increase the dissolution rate of Rosuvastatin Calcium, a poorly water soluble drug and hence improve its oral bioavailability by Nanosuspension technology. Nanosuspension is new carrier free colloidal drug delivery system with nano sized particles below 1000 nm, and considered as a great drug delivery technique to enhance the drug dissolution and solubility. In the present work Nanosuspension is made by nanoprecipitation technique in the presence of sodium lauryl sulfate as surfactant and PVPK-30 as stabilizer. Prepared Nanosuspension was evaluated for its particle size study, in vitro dissolution study and characterized by Screening Electron microscopy (SEM). Different concentrations of sodium lauryl sulphate (SLS) and PVPK-30 were evaluated. All formulations were in the nano size and showed marked improvement in dissolution and solubility compared to pure drug of micron size. Finally it was concluded that formulating poorly soluble drugs in the form of Nanosuspension would be a promising approach in delivery of poor water soluble drugs by oral route in a simple and effective way.
Authors and Affiliations
Raturi Ankita, Bhatt Ganesh,, Kothiyal Preeti
Keywords
Related Articles
- EP ID EP338168
- DOI -
- Views 135
- Downloads 0
STEVIA AN UNTOUCHED NATURE’S GIFT CAN BE A BOON TO DIABETIC
Plants and fungi are a vital part of healthcare. Over 80% of the global population rely on traditional medicine, much of which is based on plant remedies. Traditional Chinese medicine alone uses over 5,000 plant species....
INTERNATIONAL CONFERENCE ON HARMONISATION: AN OVERVIEW
The International Conference on Harmonisation (ICH) is a project that makes together the regulatory bodies of Europe, Japan and the United States and professionals from the pharmaceutical domain in the three areas to dis...
OVERVIEW OF DRUG REGULATORY AFFAIRS AND REGULATORY PROFESSION
Pharmaceutical drug regulatory affairs govern registration parameters of pharmaceutical products. It has a broad spectrum covering all aspects of documentation and marketing in legalized form. The pharmaceutical industry...
REGULATIONS GOVERNING CLINICAL TRIALS IN INDIA, EUROPE AND USA COMPARATIVE STUDY
Clinical trials are research studies that explore whether a medical strategy, treatment, or device is safe and effective for humans. These studies also may show which medical approaches work best for certain illnesses or...
SCALE UP AND POSTAPPROVAL CHANGES (SUPAC) GUIDANCE FOR INDUSTRY: A REGULATORY NOTE
In today scenario, as per market demand there is definitely carry out an increment or decrease in production, this is called SUPAC. Different guidelines are provided for those different types of SUPAC in by different reg...