FORMULATION AND EVALUATION OF NOVEL SUSTAINED RELESE CAPSULES OF TERBUTALINE SULPHATE
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2011, Vol 2, Issue 1
Abstract
Terbutaline sulphate is a direct acting sympathomimetic agent with predominantly β- adrenergic activity and a selective action on β2-receptors, which is widely used in the prophylaxis and control of asthma. In the present investigation, the empty gelatin capsules (body) were cross linked by exposing to the vapours of formaldehyde in order to extend the drug release. The drug was filled in to the cross linked capsules by using hand filling method. Macroscopical features revealed that drug was dispersed in the polymer matrix. The empty capsules were subjected for various physicochemical tests like appearance, dimension, identification, weight and moisture content. The prepared capsules were evaluated for their thickness, content uniformity, weight variation, disintegration and in-vitro dissolution. The average weight and thickness of all the capsules were uniform. In-vitro dissolution studies showed a burst release initially followed by a progressive fall and a constant release of the drug and extended up to 8 to 10 hours. Release kinetics of terbutaline sulphte from cross linked capsules followed the first order release profile.
Authors and Affiliations
Abdul Khan , Mohammed Ahmed , B Ramesh
Keywords
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