FORMULATION AND EVALUATION OF ROPINIROLE SUSTAINED RELEASED TABLETS BY USING NATURAL AND SYNTHETIC POLYMERS
Journal Title: Int J of Pharm Rev& Res - Year 2015, Vol 5, Issue 1
Abstract
The main aim of proposed work was to develop Ropinirole matrix tablets sustained release dosage form, Ropinirole is Parkinson’s disease the sustained release formulation is the drug delivery system that is designed to achieve a prolonged therapeutic effect by continuously releasing medication over an extended period of time after administration of single dose. The sustained release tablets were prepared by direct compression method using Hydroxy propylmethyl cellulose (K15M, K100M), sodium alginate, and guar gum, in varying ratios. Tablets blends were evaluated for loose bulk density, tapped bulk density, compressibility index and angle of repose, shows satisfactory results. The compressed tablets were then evaluated for various physical tests like diameter, thickness, uniformity of weight, hardness, friability, and drug content. The granules exhibited satisfactory rheological demeanor. The results of all these tests were found to be satisfactory. The in vitro dissolution study was carried out for 24 hours. 500 RPM using paddle after 4hrs 0.1N HCL was replaced in phosphate buffer (pH 6.8) as dissolution media. Formulation F1 to F12direct compression method, sustain release and among all the formulation. This finding reveals that above a particular concentration of HPMCK100M, K15M, sodium alginate and Guar gum, Mg stearate are capable of providing sustained drug release.
Authors and Affiliations
V. Naga Manoj kiran1 , Arun kumar B1 , Sharadha srikanth1 , V. Uma Maheshwara Rao2
Keywords
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