FORMULATION AND EVALUATION OF STAVUDINE LOADED SODIUM ALGINATE BEADS BY IONOTROPIC GELATION METHOD
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2014, Vol 5, Issue 9
Abstract
The objective of the present study was to develop hydrophilic polymer and hydrophobic polymer based novel control release Stavudine beads for achieving the action up to 12 h and to characterize the efficacy and to analyze the effect of various polymers. The Stavudine beads were prepared by ionotropic gelation method from sodium alginate solution containing HPMC and ethyl cellulose in various ratios in order to get the required theoretical release profile. The result of FTIR spectra and DSC study indicated the stability and compatibility of the drug with the polymers used. The standard curve has been observed in both 0.1 N HCl and phosphate buffer pH 6.8 which showed a regression of 0.990 and 0.993 respectively. When observed through optical microscopy, the particle sizes ranged from 5.52 mm to 8.00 mm. The maximum amount of drug content was found to be 47.3 mg. From the results, it was concluded that the release rate of drug is slow and consistent in drug: polymer (HPMC K4M) ratio of 1:3 than the other formulations. Scanning electron microscopy showed that the beads were spherical with smooth surface. The percentage of encapsulation efficiency and in-vitro drug release of the best batch F4 was 94.62 % and 66.4 % in 12 h respectively showing a better controlled release of drug. The in-vitro release data was treated with mathematical equations, the drug release from the beads were ascertain and found to be First order and the mechanism of drug release followed Peppa’s model with non-Fickian equation.
Authors and Affiliations
Revathi Sundaramoorthy , Madhulatha Vuyyuru , Dasaratha Magharla
Keywords
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- EP ID EP157997
- DOI 10.7897/2230-8407.0509144
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