FORMULATION AND EVALUATION OF SULPHAMETHOXAZOLE SUSPENSION BY PH CHANGE METHODS
Journal Title: Int J of Pharm Res & Analy - Year 2015, Vol 5, Issue 2
Abstract
Dispersed phase preparation is an important step in the formulation of suspensions. One of the good criteria for suspension is fine (micron) sized dispersed phase particles. Fine size of the particles in a suspension is required for good physical stability and rapid dissolution rate. The particle size in a suspension can be reduced by techniques such as by micronisation using various size reduction machineries and also by pharmaceutical techniques such as co-precipitation and pH change method. The objective of this study was to prepare and evaluate sulphamethoxazole suspension by pH change method. The plots of sedimentation volume versus time indicated slow settling of dispersed particles in the case of suspensions prepared by pH change method when compared to control formulations. These results indicated that the dispersed phase particles remain suspended over a longer period of time in the case of suspensions prepared by pH change method. The better suspendability of the particles in the suspensions prepared by pH change method is due to reduction in particle size.
Authors and Affiliations
Ramya Krishna Seelam1 , Eliyas Kadi Abafita1
Keywords
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