Formulation and Evaluation of Sustained Release Gastro-retentive Drug Delivery System of Acyclovir Leading to Enhanced Bioavailability
Journal Title: Journal of Pharmaceutical Research International - Year 2015, Vol 7, Issue 6
Abstract
Objective: The objective was formulation and characterization of low-density gastro-retentive microspheres of Acyclovir (ACV) using hydroxyl propyl methyl cellulose to enhanced retention time and bioavailability. Materials and Methods: HPMCK4M was used as polymer for forming microspheres and Poly Vinyl Alcohol as stabilizing agent. The microspheres were characterized with respect to their morphology, particle size, encapsulation efficiency, production yield, in-vitro release and pharmacokinetic study in rats. The mean particle size was within range and showed spherical shape. Results and Discussion: Microspheres were having sufficient entrapment efficiency and floating ability and were directly proportional to the polymer concentration. In-vitro and pharmacokinetic study in rats proved the efficiency of microspheres in sustaining the drug release for 12 hrs as compared to oral suspension of ACV. Conclusion: The floating microspheres of ACV are potential drug delivery system for the enhancement of oral bioavailability of ACV.
Authors and Affiliations
Sunil Kumar Mishra, Smriti Khatri
Keywords
Related Articles
- EP ID EP344700
- DOI 10.9734/BJPR/2015/19116
- Views 97
- Downloads 0
In-vitro Studies of Food Interaction with Dihydroartemisinin – Piperaquine Antimalarial Tablet
The study assessed molecular interactions between the actives in antimalarial dihydroartemisinin-piperaquine (DP) tablet and food components using Fourier transform infrared spectroscopy (FTIR). Soluble starch, lactose,...
In-vitro Evaluation of Cytotoxic and Anthelmintic Activity of Luffa acutangula, Luffa aegyptiaca and Momordica cochinchinensis
Aims: The study was designed to investigate cytotoxic and anthelmintic activity of aerial parts of Luffa acutangula (L.) Roxb. (Family: Cucurbitaceae, locally known as ‘Jhinga’), Luffa aegyptiaca Mill. (Family: Cucurbita...
Acute Effects of Intravenous Administration of Polyunsaturated Fatty Acids on Blood Pressure and Heart Rate in U46619- and Noradrenaline-infused Rats
Experimental studies and epidemiological surveys have indicated that chronic oral administration of the n-3 polyunsaturated fatty acids (PUFAs) docosahexaenoic (DHA) or eicosapentaenoic (EPA) acids reduces blood pressure...
Antioxidant Activity and Biochemical Screening of two Glycyrrhiza L. Species
Aims: Glycyrrhiza L. is one of the most widely used plants in traditional medicine since antiquity. For the determining of the biochemical composition and antioxidant activity of methanolic extracts of two Glycyrrhiza sp...
Evaluation of Novel Solid Lipid Microparticles Drug Delivery Systems for Oral Delivery of a Herbal Antidiabetic Extract
Aim: The aim of the present study was to prepare and evaluate a novel multiparticulate pharmaceutical formulation of Vernonia amygdalina extract suitable for oral administration. Study Design: Solid lipid microparticles...